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Very-low-calorie diet-based intensive lifestyle intervention for remission of type 2 diabetes: Real-world experience in a South Asian population.
Dissanayake, H A; Fernando, D R; Nilaweera, A I; Munasinghe, T D; Kaushalya, C M A U; Pulukkody, M M; Katulanda, P.
Afiliación
  • Dissanayake HA; Diabetes Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Fernando DR; Diabetes Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Nilaweera AI; Diabetes Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Munasinghe TD; Diabetes Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Kaushalya CMAU; Diabetes Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Pulukkody MM; Centre for Diabetes Endocrinology and Metabolism, Colombo, Sri Lanka.
  • Katulanda P; Diabetes Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Diabet Med ; : e15422, 2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39118237
ABSTRACT

AIMS:

Very low-calorie diet (VLCD) can induce weight loss and diabetes remission (DR) amongst people with obesity and recent-onset type 2 diabetes (T2D). We aimed to determine the effectiveness and acceptability of VLCD in achieving DR amongst Sri Lankan adults with T2D.

METHODS:

A retrospective analysis was conducted in a diabetes practice where VLCD-based Diabetes Remission Programme (VDRP) was offered for adults (>18 years) with T2D for <3 years and body mass index over 25 kg/m2. VLCD (~800 kcal/day, provided with/without diet replacement formula) was offered for 8-12 weeks, followed by gradual food reintroduction and exercise. DR was defined as HbA1c <6.5% at least 3 months after stopping glucose-lowering medications.

RESULTS:

A total of 170 participants who enrolled in the VDRP (mean age 38.4 years [±11.1], men 68%, mean baseline HbA1c 86.9 [±18.1] mmol/mol (10.1 [±2.1]%), median duration of T2D 2 years [IQR 1-2]) and 87 (51%) of them followed the programme (attended at least one follow-up visit). Amongst the individuals who followed the VDRP, 40.2% achieved DR (35/87), compared with 2.4% (2/83) amongst those who did not follow the VDRP (aHR 9.3, 95% CI 2.2-16.4, p = 0.002). The proportion achieving normoglycaemia (HbA1c < 6.5%) but continued to take glucose-lowering medication was 20/87 among VDRP followers and 20/85 amongst VDRP non-followers. The commonest reasons for not following the VDRP were too restrictive dietary quantity (92%) and difficulties in finding recommended food items (67%). Majority (79%) would recommend VDRP to others.

CONCLUSIONS:

VDRP is effective in achieving T2D remission amongst Sri Lankan adults with recently diagnosed T2D and obesity. Over half of the participants followed the programme and over 75% would recommend it to others, indicating good acceptability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabet Med Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Sri Lanka Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabet Med Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Sri Lanka Pais de publicación: Reino Unido