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Interpreting urinary iodine concentration: effects of urine dilution and collection timing.
Oblak, Adrijana; Hribar, Masa; Hristov, Hristo; Gregoric, Matej; Blaznik, Urska; Osredkar, Josko; Kusar, Anita; Zmitek, Katja; Lavrisa, Ziva; Zaletel, Tjasa; Krhin, Blaz; Pravst, Igor; Gaberscek, Simona; Zaletel, Katja.
Afiliación
  • Oblak A; Division of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Hribar M; Nutrition Institute, Ljubljana, Slovenia.
  • Hristov H; Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
  • Gregoric M; Nutrition Institute, Ljubljana, Slovenia.
  • Blaznik U; National Institute of Public Health, Ljubljana, Slovenia.
  • Osredkar J; National Institute of Public Health, Ljubljana, Slovenia.
  • Kusar A; Clinical Institute for Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Zmitek K; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
  • Lavrisa Z; Nutrition Institute, Ljubljana, Slovenia.
  • Zaletel T; Nutrition Institute, Ljubljana, Slovenia.
  • Krhin B; VIST-Higher School of Applied Sciences, Ljubljana, Slovenia.
  • Pravst I; Nutrition Institute, Ljubljana, Slovenia.
  • Gaberscek S; School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Zaletel K; Division of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Eur J Clin Nutr ; 2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39117906
ABSTRACT

OBJECTIVES:

In population studies, iodine intake estimation relies on median urinary iodine concentration (UIC). However, interpreting UIC measurements can be challenging.

METHODS:

In our study, we included 772 adult participants from three groups nationally representative gender-mixed, women of reproductive age, and pregnant women. We measured UIC and urinary creatinine (U-Cr) to calculate the iodine-to-creatinine ratio (I/Cr). U-Cr cut-off value of 0.226 g/L was used for differentiation between diluted and undiluted urine samples. After excluding samples below this cut-off, new median UIC and I/Cr ratios were calculated. We additionally evaluated the influence of urine sample collection time on UIC.

RESULTS:

Median UICs were 91.8 µg/L for nationally representative group, 58.3 µg/L for women of reproductive age, and 74.9 µg/L for pregnant women, while I/Cr ratios were 91.7, 102.0, and 159.2 µg/g, respectively. After implementing U-Cr cut-off and excluding all data where U-Cr was below cut-off, new median values were 93.4, 76.3, and 95.4 µg/L for UICs, and 88.6, 88.8, and 128.7 µg/g for I/Cr ratios, respectively. In women of reproductive age, median UIC was significantly lower in urine samples collected after 930 and after 1200 as compared to samples collected before 9.30 (53.4, 57.8, and 97.3 µg/L, respectively).

CONCLUSIONS:

UIC results should be interpreted with caution, considering urine dilution and sample collection timing. U-Cr measurement should be included in population-based iodine intake studies, with corrections applied especially for pregnant women and younger adults, for whom morning is best for single-spot samples.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Clin Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Clin Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Reino Unido