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Prenatal organophosphate pesticide exposure and sex-specific estimated Fetal size.
Medley, Eleanor A; Trasande, Leonardo; Naidu, Mrudula; Wang, Yuyan; Ghassabian, Akhgar; Kahn, Linda G; Long, Sara; Afanasyeva, Yelena; Liu, Mengling; Kannan, Kurunthachalam; Mehta-Lee, Shilpi S; Cowell, Whitney.
Afiliación
  • Medley EA; Department of Population Health, New York University School of Medicine, New York, NY, USA.
  • Trasande L; Department of Population Health, New York University School of Medicine, New York, NY, USA.
  • Naidu M; Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
  • Wang Y; New York University School of Global Public Health, New York, New York, USA.
  • Ghassabian A; Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
  • Kahn LG; Department of Population Health, New York University School of Medicine, New York, NY, USA.
  • Long S; Department of Population Health, New York University School of Medicine, New York, NY, USA.
  • Afanasyeva Y; Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
  • Liu M; Department of Population Health, New York University School of Medicine, New York, NY, USA.
  • Kannan K; Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
  • Mehta-Lee SS; Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
  • Cowell W; Department of Population Health, New York University School of Medicine, New York, NY, USA.
Am J Epidemiol ; 2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39117571
ABSTRACT
Prenatal organophosphate (OP) pesticide exposure may be associated with reduced fetal growth, although studies are limited and have mixed results. We investigated associations between prenatal OP pesticide exposure and fetal size and modification by fetal sex. Maternal urinary concentrations of dialkyl phosphate (DAP) metabolites were measured at three time points. Fetal biometrics were obtained from ultrasounds in the second (n=773) and third (n=535) trimesters. Associations between pregnancy-averaged ΣDAP and fetal biometry z-scores were determined through multiple linear regression. Modification by sex was investigated through stratification and interaction. In the second trimester, one ln-unit increase in ΣDAP was associated with lower estimated fetal weight (-0.15 SD; 95% CI -0.29, -0.01), head circumference (-0.11 SD; CI -0.22, 0.01), biparietal diameter (-0.14 SD; CI -0.27, -0.01), and abdominal circumference (-0.12 SD; CI -0.26, 0.01) in females. In the third trimester, one ln-unit increase in ΣDAP was associated with lower head circumference (-0.14 SD; CI -0.28, 0.00) and biparietal diameter (-0.12 SD; CI -0.26, 0.03) in males. Our results suggest that prenatal OP pesticide exposure is negatively associated with fetal growth in a sex-specific manner, with associations present for females in mid-gestation and males in late gestation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Epidemiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Epidemiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos