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Impact of Lactobacillaceae supplementation on the multi-organ axis during MASLD.
Santos, André A; Duarte, Raquel; Duarte, Madalena; Arella, Fabiola; Marques, Vanda; Roos, Stefan; Rodrigues, Cecília M P.
Afiliación
  • Santos AA; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal. Electronic address: afasantos@ff.ulisboa.pt.
  • Duarte R; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal.
  • Duarte M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal.
  • Arella F; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal.
  • Marques V; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal.
  • Roos S; Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences, Sweden.
  • Rodrigues CMP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal.
Life Sci ; 354: 122948, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-39117140
ABSTRACT
The gut-liver axis plays a pivotal role in maintaining body homeostasis. Disruption of the gut-liver axis is linked to a multitude of diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Probiotic strains from the Lactobacillaceae family are commonly used to mitigate experimental MASLD. Over the years, numerous studies have demonstrated the efficacy of these probiotics, often focusing on the outcome of liver disease. This review aims to further understand MASLD as a systemic metabolic dysfunction and to highlight the effects of probiotics on multi-organ axis, including organs such as the gastrointestinal tract, pancreas, muscle, adipose tissue, and the immune system. We specifically discuss evidence on how supplementation with Lactobacillaceae strains may alleviate MASLD by not only restoring liver health but also by modulating the physiology of other organ systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Suplementos Dietéticos Límite: Animals / Humans Idioma: En Revista: Life Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Suplementos Dietéticos Límite: Animals / Humans Idioma: En Revista: Life Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos