Your browser doesn't support javascript.
loading
The Safety of Intraoperative Photodynamic Diagnosis Using 5-Aminolevulinic Acid Combined with Talaporfin Sodium Photodynamic Therapy in Recurrent High-Grade Glioma.
Kohzuki, Hidehiro; Miki, Shunichiro; Sugii, Narushi; Tsurubuchi, Takao; Zaboronok, Alexander; Matsuda, Masahide; Ishikawa, Eiichi.
Afiliación
  • Kohzuki H; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Miki S; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Sugii N; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Tsurubuchi T; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Zaboronok A; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Matsuda M; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Ishikawa E; Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: e-ishikawa@md.tsukuba.ac.jp.
World Neurosurg ; 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39116940
ABSTRACT

BACKGROUND:

Intraoperative photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) is a widely adopted technique to enhance the extent of resection during high-grade glioma (HGG) surgery. Recent updates to the package insert for 5-ALA in Japan now allow its use in combination with drugs that may induce photosensitivity, such as talaporfin sodium (TS). TS is employed in intraoperative photodynamic therapy (PDT) and has been shown to improve overall survival. The combination of 5-ALA with TS is expected to offer further benefits. However, the safety of this combination had not been established. This study reports on the safety of 5-ALA-PDD with TS-PDT in the treatment of recurrent HGG.

METHODS:

7 patients with recurrent HGG underwent tumor resection using a combination of 5-ALA-PDD and TS-PDT. The incidence of photosensitivity as an adverse effect associated with 5-ALA and TS was evaluated as described in the package insert. Adverse events were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

RESULTS:

Tumor-specific fluorescence intensity was strong in 4 cases and weak in 3. Photosensitivity occurred in only 1 patient (14.3%). Three patients exhibited CTCAE grade 1 or 2 abnormal liver function, and 1 patient experienced CTCAE grade 1 γ-GTP elevation. All abnormalities improved during follow-up.

CONCLUSIONS:

The combined use of 5-ALA-PDD and TS-PDT for HGG surgery did not increase the risk of serious adverse events in our study. Further investigations with a larger number of cases are needed for a more accurate assessment of its safety and efficacy.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos