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Panax notoginseng saponins dually modulates autophagy in gastric precancerous lesions complicated with myocardial ischemia-reperfusion injury model through the PI3K/AKT/mTOR pathway.
Wang, Xiaoyan; Zhang, Ruihang; Zeng, Nili; Li, Hao; Hua, Baojin.
Afiliación
  • Wang X; Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Huajiadi Street, Chaoyang District, Beijing 100102, China; Tibetan Medicine Administration of Tibet Autonomous Region, Tibetan 850000, China.
  • Zhang R; Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Huajiadi Street, Chaoyang District, Beijing 100102, China.
  • Zeng N; Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Huajiadi Street, Chaoyang District, Beijing 100102, China.
  • Li H; Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Huajiadi Street, Chaoyang District, Beijing 100102, China. Electronic address: wjhplihao1965@126.com.
  • Hua B; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5, Beixiangge, Xicheng District, Beijing 100053, China. Electronic address: drhuabaojin@126.com.
Biomed Pharmacother ; 178: 117268, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39116780
ABSTRACT
Gastric precancerous lesion (GPL) is a crucial stage in the development of gastric cancer, characterized by incomplete intestinal epithelial chemotaxis and heterogeneous hyperplasia with high malignant potential. Early intervention in GPL is vital for preventing gastric cancer. Additionally, there are shared risk factors and pathogenesis between tumors and coronary heart disease (CHD), with an increasing number of tumor patients GPL complicated with CHD due to improved survival rates. Reperfusion therapy in CHD can result in myocardial ischemia-reperfusion injury (MIRI). Traditional Chinese medicine (TCM) has demonstrated unique advantages in treating GPL and MIRI by promoting blood circulation and removing blood stasis. Panax ginseng total saponin (PNS), a component of TCM known for its blood circulation benefits, has shown positive effects in inhibiting tumor growth and improving myocardial ischemia. This study utilized a GPL-MIRI mouse model to investigate the effects of PNS in treatment. Results indicated that PNS significantly improved typical GPL lesions in mice, such as incomplete intestinal epithelialization and heteroplasia, and also reduced myocardial infarction. At the molecular level, PNS exhibited a bidirectional regulatory role in the GPL-MIRI model. It enhanced the autophagic process in gastric mucosal cells by inhibiting the PI3K/Akt/mTOR signaling pathway, while suppressed excessive autophagy in cardiomyocytes. These findings offer new insights and treatment strategies for managing GPL and MIRI using the TCM compound PNS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Autofagia / Neoplasias Gástricas / Daño por Reperfusión Miocárdica / Transducción de Señal / Panax notoginseng Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2024 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Autofagia / Neoplasias Gástricas / Daño por Reperfusión Miocárdica / Transducción de Señal / Panax notoginseng Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2024 Tipo del documento: Article Pais de publicación: Francia