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TRPC1: The housekeeper of the hippocampus.
Skerjanz, Julia; Bauernhofer, Lena; Lenk, Kerstin; Emmerstorfer-Augustin, Anita; Leitinger, Gerd; Reichmann, Florian; Stockner, Thomas; Groschner, Klaus; Tiapko, Oleksandra.
Afiliación
  • Skerjanz J; Gottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Austria.
  • Bauernhofer L; Biophysics Division, Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria; BioTechMed-Graz, Austria.
  • Lenk K; Institute of Neural Engineering, Graz University of Technology, Austria; BioTechMed-Graz, Austria.
  • Emmerstorfer-Augustin A; Institute of Molecular Biotechnology, Graz University of Technology, Austria; BioTechMed-Graz, Austria.
  • Leitinger G; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Austria; BioTechMed-Graz, Austria; MEFOgraz, Austria.
  • Reichmann F; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria; BioTechMed-Graz, Austria.
  • Stockner T; Department of Pharmacology, Medical University of Vienna, Vienna, Austria.
  • Groschner K; Gottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Austria.
  • Tiapko O; Gottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Austria; BioTechMed-Graz, Austria; MEFOgraz, Austria. Electronic address: oleksandra.tiapko@medunigraz.at.
Cell Calcium ; 123: 102933, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39116710
ABSTRACT
The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales Catiónicos TRPC / Hipocampo Límite: Animals / Humans Idioma: En Revista: Cell Calcium Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales Catiónicos TRPC / Hipocampo Límite: Animals / Humans Idioma: En Revista: Cell Calcium Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos