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Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults.
Sampaio, Joana; Pinto, Joana; Pizarro, Andreia; Oliveira, Bruno; Moreira, André; Padrão, Patrícia; Moreira, Pedro; Guedes de Pinho, Paula; Carvalho, Joana; Barros, Renata.
Afiliación
  • Sampaio J; Faculty of Sport (FADEUP), University of Porto, Porto, Portugal; Research Centre in Physical Activity, Health, and Leisure (CIAFEL), University of Porto, Porto, Portugal; Epidemiology Unit (EPIUnit), Public Health Institute (ISPUP), University of Porto, Porto, Portugal; Laboratory for Integrative an
  • Pinto J; Associate Laboratory i4HB - Institute for Health and Bioeconomy, University of Porto, Porto, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal.
  • Pizarro A; Faculty of Sport (FADEUP), University of Porto, Porto, Portugal; Research Centre in Physical Activity, Health, and Leisure (CIAFEL), University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
  • Oliveira B; Faculty of Nutrition and Food Sciences (FCNAUP), University of Porto, Porto, Portugal.
  • Moreira A; Epidemiology Unit (EPIUnit), Public Health Institute (ISPUP), University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal; Faculty of Medicine (FMUP), University of Porto, Porto, Portugal.
  • Padrão P; Epidemiology Unit (EPIUnit), Public Health Institute (ISPUP), University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal; Faculty of Nutrition and Food Sciences (FCNAUP), University of Porto, Porto, Portugal.
  • Moreira P; Research Centre in Physical Activity, Health, and Leisure (CIAFEL), University of Porto, Porto, Portugal; Epidemiology Unit (EPIUnit), Public Health Institute (ISPUP), University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portu
  • Guedes de Pinho P; Associate Laboratory i4HB - Institute for Health and Bioeconomy, University of Porto, Porto, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal.
  • Carvalho J; Faculty of Sport (FADEUP), University of Porto, Porto, Portugal; Research Centre in Physical Activity, Health, and Leisure (CIAFEL), University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal. Electronic address: jcarvalho@
  • Barros R; Epidemiology Unit (EPIUnit), Public Health Institute (ISPUP), University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal; Faculty of Nutrition and Food Sciences (FCNAUP), University of Porto, Porto, Portugal. Electronic add
Clin Nutr ; 43(9): 2125-2135, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39116619
ABSTRACT
BACKGROUND AND

AIMS:

Healthy dietary patterns and exercise practices have been associated with improved metabolic and inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers and metabolome in older adults are sparser. The primary aim of this study was to investigate the impact of a combined Mediterranean Diet-based Sustainable Healthy Diet (SHD) and Multicomponent Training (MT) intervention on the plasma biomarkers and metabolome and how dietary intake and exercise could modulate these effects.

METHODS:

SHD intervention included a weekly supply of Mediterranean Diet-based SHD food and four nutrition sessions involving a Mediterranean-Diet culinary workshop, and the exercise program included 50-min MT group sessions, held three times a week, lasting both 12 weeks. Plasma biomarkers were obtained through standard biochemical analysis. A proton (1H) nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach was used to study the metabolome in blood plasma. Repeated measures ANOVA were performed and adjusted for confounders.

RESULTS:

SHD + MT intervention significantly decreased HDL-C and calcium. SHD + MT showed some changes in common with the SHD and MT group, namely a significant decrease in citrate levels (p = 0.009 for SHD + MT; p = 0.037 for SHDT) and an increase in pyruvate (p < 0.001 for MT and SHD + MT). The SHD + MT group also revealed specific changes in the levels of some amino acids (decrease in alanine, glutamine and lysine p = 0.026; p < 0.001; p = 0.038, respectively). Increases in formate (p = 0.025) and unsaturated lipids (p = 0.011) are consistent with changes in energy and lipoprotein metabolism.

CONCLUSION:

Our data show that a combined lifestyle intervention program, including a Mediterranean Diet-based SHD and MT, could modulate biomarker and metabolome and there seems to be a metabolic path associated to these interventions in older adults. Due to its wide-ranging relevance, it is pertinent to assess to what extent combined SHD and MT can contribute to better clinical profiles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Ejercicio Físico / Dieta Mediterránea / Metaboloma / Dieta Saludable Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Ejercicio Físico / Dieta Mediterránea / Metaboloma / Dieta Saludable Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido