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Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda.
Batte, Charles; Semulimi, Andrew Weil; Mukisa, John; Nakabuye, Mariam; Nidoi, Jasper; Mukunya, David; Ratanshi, Rosalind Parkes; Castelnuovo, Barbara; Lamorde, Mohammed; Meya, David; Checkley, William; Kalyesubula, Robert; Siddharthan, Trishul; Babigumira, Joseph B.
Afiliación
  • Batte C; Department of Medicine, Lung Institute, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Semulimi AW; Department of Medicine, Lung Institute, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Mukisa J; Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Nakabuye M; Department of Medicine, Lung Institute, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Nidoi J; Department of Medicine, Lung Institute, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Mukunya D; Department of Community and Public Health, Faculty of Health Sciences, Busitema University, Tororo, Uganda.
  • Ratanshi RP; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Castelnuovo B; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
  • Lamorde M; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Meya D; Infectious Diseases Institute, Makerere University, Kampala, Uganda.
  • Checkley W; Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Kalyesubula R; Center for Global Non-Communicable Diseases Research and Training, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
  • Siddharthan T; Department of Physiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Babigumira JB; Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
PLoS One ; 19(8): e0306928, 2024.
Article en En | MEDLINE | ID: mdl-39116145
ABSTRACT

INTRODUCTION:

The presence of hypertension could reduce the health-related quality of life (HRQoL) of people with HIV (PWH). Yet, literature describing the HRQoL of PWH who have hypertension in Uganda is scarce making the design of locally adapted interventions cumbersome. In our study, we compared HRQoL scores of people with HIV with and without hypertension on long term antiretroviral therapy (ART) in Uganda.

METHODS:

We recruited 149 PWH with hypertension and 159 PWH without hypertension in the long-term ART cohort at an urban clinic in Kampala, Uganda. Data on socio-demographics were collected using an interviewer designed questionnaire while data on the World Health Organisation clinical stage viral load and CD4 count as well as ART duration were extracted from clinic electronic database and a generic EuroQol -5D- 5L (EQ-5D- 5L) and Medical Outcome Study (MOS-HIV) questionnaire used to collect HRQoL data. Data were summarized using descriptive statistics while inferential statistics were used to determine associations between key variables and HRQoL. Mann-Whitney U tests were used to compare HRQoL between groups of interest.

RESULTS:

One hundred ninety (61.7%) participants were female. PWH who had hypertension were older (Mean ± SD 53.7 ± 8.3 vs 49.9 ± 8.6, p value <0.001) than those without hypertension. Participants with hypertension had lower overall median health utility scores (0.71 (0.33-0.80) vs 0.80 (0.44-0.80), p value = 0.029) and mean physical health score (48.44 ± 10.17 vs 51.44 ± 9.65, p value < 0.001) as opposed to those without hypertension. Hypertension (p value = 0.023), high income status, >70,000 UGX, (p value = 0.044), disclosure of the HIV status of the participants to their partner (p value = 0.026), and current history of smoking (p value = 0.029) were associated with low HRQoL scores.

CONCLUSION:

Among people with HIV, those with hypertension had lower HRQoL compared to those without. This calls for inclusion of quality-of-life assessment in the management of PWH who have been diagnosed with hypertension to identify those at risk and plan early interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Infecciones por VIH / Hipertensión Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Infecciones por VIH / Hipertensión Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Estados Unidos