The Role of Long Noncoding RNAs in Vascular Smooth Muscle Cell Phenotype and the Pathogenesis of Cardiovascular and Cerebrovascular Aneurysms.
J Cardiovasc Pharmacol
; 84(2): 125-135, 2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-39115715
ABSTRACT
ABSTRACT Aneurysms are localized dilations of blood vessels, which can expand to 50% of the original diameter. They are more common in cardiovascular and cerebrovascular vessels. Rupture is one of the most dangerous complications. The pathophysiology of aneurysms is complex and diverse, often associated with progressive vessel wall dysfunction resulting from vascular smooth muscle cell death and abnormal extracellular matrix synthesis and degradation. Multiple studies have shown that long noncoding RNAs (lncRNAs) play a significant role in the progression of cardiovascular and cerebrovascular diseases. Therefore, it is necessary to find and summarize them. LncRNAs control gene expression and disease progression by regulating target mRNA or miRNA and are biomarkers for the diagnosis and prognosis of aneurysmal cardiovascular and cerebrovascular diseases. This review explores the role, mechanism, and clinical value of lncRNAs in aneurysms, providing new insights for a deeper understanding of the pathogenesis of cardiovascular and cerebrovascular aneurysms.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenotipo
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Aneurisma Intracraneal
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Miocitos del Músculo Liso
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ARN Largo no Codificante
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Músculo Liso Vascular
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos