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The effects of cGAS-STING inhibition in liver disease, kidney disease, and cellular senescence.
Wang, Ling; Zhang, Zhengwei; Zhang, Haichao; Zhou, Minmin; Huang, Cheng; Xia, Wenjiang; Li, Jun; You, Hongmei.
Afiliación
  • Wang L; Department of Pharmacy, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
  • Zhang Z; Department of Pharmacy, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
  • Zhang H; Department of Pharmacy, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
  • Zhou M; Department of Pharmacy, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
  • Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
  • Xia W; Department of Pharmacy, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
  • Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
  • You H; Department of Pharmacy, Hangzhou Women's Hospital, Hangzhou, China.
Front Immunol ; 15: 1346446, 2024.
Article en En | MEDLINE | ID: mdl-39114669
ABSTRACT
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is one of the fundamental mechanisms of the body's defense, which responds to the abnormal presence of double-stranded DNA in the cytoplasm to establish an effective natural immune response. In addition to detecting microbial infections, the cGAS pathway may be triggered by any cytoplasmic DNA, which is absent from the normal cytoplasm, and only conditions such as senescence and mitochondrial stress can lead to its leakage and cause sterile inflammation. A growing body of research has shown that the cGAS-STING pathway is strongly associated with sterile inflammation. In this study, we reviewed the regulatory mechanisms and biological functions of the cGAS-STING pathway through its involvement in aseptic inflammation in liver disease, kidney disease, and cellular senescence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Senescencia Celular / Enfermedades Renales / Hepatopatías / Proteínas de la Membrana / Nucleotidiltransferasas Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Senescencia Celular / Enfermedades Renales / Hepatopatías / Proteínas de la Membrana / Nucleotidiltransferasas Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza