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Decreasing the physical gap in the neural-electrode interface and related concepts to improve cochlear implant performance.
Vecchi, Joseph T; Claussen, Alexander D; Hansen, Marlan R.
Afiliación
  • Vecchi JT; Department of Molecular Physiology and Biophysics, Carver College of Medicine, Iowa City, IA, United States.
  • Claussen AD; Department of Otolaryngology Head-Neck Surgery, Carver College of Medicine, Iowa City, IA, United States.
  • Hansen MR; Department of Otolaryngology Head-Neck Surgery, Carver College of Medicine, Iowa City, IA, United States.
Front Neurosci ; 18: 1425226, 2024.
Article en En | MEDLINE | ID: mdl-39114486
ABSTRACT
Cochlear implants (CI) represent incredible devices that restore hearing perception for those with moderate to profound sensorineural hearing loss. However, the ability of a CI to restore complex auditory function is limited by the number of perceptually independent spectral channels provided. A major contributor to this limitation is the physical gap between the CI electrodes and the target spiral ganglion neurons (SGNs). In order for CI electrodes to stimulate SGNs more precisely, and thus better approximate natural hearing, new methodologies need to be developed to decrease this gap, (i.e., transitioning CIs from a far-field to near-field device). In this review, strategies aimed at improving the neural-electrode interface are discussed in terms of the magnitude of impact they could have and the work needed to implement them. Ongoing research suggests current clinical efforts to limit the CI-related immune response holds great potential for improving device performance. This could eradicate the dense, fibrous capsule surrounding the electrode and enhance preservation of natural cochlear architecture, including SGNs. In the long term, however, optimized future devices will likely need to induce and guide the outgrowth of the peripheral process of SGNs to be in closer proximity to the CI electrode in order to better approximate natural hearing. This research is in its infancy; it remains to be seen which strategies (surface patterning, small molecule release, hydrogel coating, etc.) will be enable this approach. Additionally, these efforts aimed at optimizing CI function will likely translate to other neural prostheses, which face similar issues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurosci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurosci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza