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Mimicking Mytilus edulis foot protein: A versatile strategy for robust biomedical coatings.
Du, Zeyu; Qiao, Feng; Tong, Liping; Zhang, Wentai; Mou, Xiaohui; Zhao, Xin; Maitz, Manfred F; Wang, Huaiyu; Huang, Nan; Yang, Zhilu.
Afiliación
  • Du Z; School of Materials Science and Engineering, Department of Cardiology, Third People's Hospital of Chengdu Affiliated with Southwest Jiaotong University, Southwest Jiaotong University, Chengdu 610031, China.
  • Qiao F; Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan 523059, China.
  • Tong L; School of Materials Science and Engineering, Department of Cardiology, Third People's Hospital of Chengdu Affiliated with Southwest Jiaotong University, Southwest Jiaotong University, Chengdu 610031, China.
  • Zhang W; Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Mou X; Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan 523059, China.
  • Zhao X; School of Materials Science and Engineering, Department of Cardiology, Third People's Hospital of Chengdu Affiliated with Southwest Jiaotong University, Southwest Jiaotong University, Chengdu 610031, China.
  • Maitz MF; Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan 523059, China.
  • Wang H; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
  • Huang N; School of Materials Science and Engineering, Department of Cardiology, Third People's Hospital of Chengdu Affiliated with Southwest Jiaotong University, Southwest Jiaotong University, Chengdu 610031, China.
  • Yang Z; Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, 01069 Dresden, Germany.
Innovation (Camb) ; 5(5): 100671, 2024 Sep 09.
Article en En | MEDLINE | ID: mdl-39114479
ABSTRACT
Universal coatings with versatile surface adhesion, good mechanochemical robustness, and the capacity for secondary modification are of great scientific interest. However, incorporating these advantages into a system is still a great challenge. Here, we report a series of catechol-decorated polyallylamines (CPAs), denoted as pseudo-Mytilus edulis foot protein 5 (pseudo-Mefp-5), that mimic not only the catechol and amine groups but also the backbone of Mefp-5. CPAs can fabricate highly adhesive, robust, multifunctional polyCPA (PCPA) coatings based on synergetic catechol-polyamine chemistry as universal building blocks. Due to the interpenetrating entangled network architectures, these coatings exhibit high chemical robustness against harsh conditions (HCl, pH 1; NaOH, pH 14; H2O2, 30%), good mechanical robustness, and wear resistance. In addition, PCPA coatings provide abundant grafting sites, enabling the fabrication of various functional surfaces through secondary modification. Furthermore, the versatility, multifaceted robustness, and scalability of PCPA coatings indicate their great potential for surface engineering, especially for withstanding harsh conditions in multipurpose biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Innovation (Camb) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Innovation (Camb) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos