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Helicobacter pylori Outer Membrane Vesicles: Biogenesis, Composition, and Biological Functions.
Li, Jiao; Liao, Tingting; Chua, Eng Guan; Zhang, Mingming; Shen, Yalin; Song, Xiaona; Marshall, Barry J; Benghezal, Mohammed; Tang, Hong; Li, Hong.
Afiliación
  • Li J; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Liao T; Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Chua EG; QuTEM AB, Gävlegatan 22, 11330 Stockholm, Sweden.
  • Zhang M; Helicobacter Research Laboratory, The Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands WA 6009, Australia.
  • Shen Y; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Song X; Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Marshall BJ; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Benghezal M; Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Tang H; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Li H; Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Int J Biol Sci ; 20(10): 4029-4043, 2024.
Article en En | MEDLINE | ID: mdl-39113715
ABSTRACT
Helicobacter pylori has been recognized not only as a causative agent of a spectrum of gastroduodenal diseases including chronic gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma, and gastric cancer, but also as the culprit in several extra-gastric diseases. However, the association of H. pylori infection with extra-gastric diseases remains elusive, prompting a reevaluation of the role of H. pylori-derived outer membrane vesicles (OMVs). Like other gram-negative bacteria, H. pylori constitutively sheds biologically active OMVs for long-distance delivery of bacterial virulence factors in a concentrated and protected form, averting the need of direct bacterial contact with distant host cells to induce extra-gastric diseases associated with this gastric pathogen. Additionally, H. pylori-derived OMVs contribute to bacterial survival and chronic gastric pathogenesis. Moreover, the immunogenic activity, non-replicable nature, and anti-bacterial adhesion effect of H. pylori OMVs make them a desirable vaccine candidate against infection. The immunogenic potency and safety concerns of the OMV contents are challenges in the development of H. pylori OMV-based vaccines. In this review, we discuss recent advances regarding H. pylori OMVs, focusing on new insights into their biogenesis mechanisms and biological functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter Límite: Animals / Humans Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter Límite: Animals / Humans Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia