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Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED.
Hetemäki, Iivo; Heikkilä, Nelli; Peterson, Pärt; Kekäläinen, Eliisa; Willcox, Nick; Anette S B, Wolff; Jarva, Hanna; Arstila, T Petteri.
Afiliación
  • Hetemäki I; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Heikkilä N; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Peterson P; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
  • Kekäläinen E; Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Willcox N; Department of Clinical Microbiology, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Anette S B W; Department of Clinical Neurosciences, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, UK.
  • Jarva H; Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Arstila TP; Department of Clinical Science, University of Bergen, Bergen, Norway.
APMIS ; 132(11): 881-887, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39113427
ABSTRACT
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, high titer neutralizing anti-type I interferon (IFN) autoantibodies have been linked with increased severity of SARS-CoV-2 and varicella zoster virus infections in APECED patients. Examining immunity against cytomegalovirus (CMV), we found a higher prevalence of anti-CMV IgG antibodies in patients with APECED (N = 19) than in 44 healthy controls (90% vs 64%, p = 0.04); the similar difference in their IgG levels did not achieve significance (95 ± 74 vs 64 ± 35 IU/mL, ns.). In contrast, the frequency of CMV-specific T cells was lower (804 ± 718/million vs 1591 ± 972/million PBMC p = 0.03). We saw no correlations between levels of anti-CMV IgG and anti-IFN antibodies in APECED patients or in a separate cohort of patients with thymoma (n = 70), over 60% of whom also had anti-IFN antibodies. Our results suggest a dysregulated response to CMV in APECED patients and highlight immunodeficiency to viral infections as part of the disease spectrum.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Inmunoglobulina G / Linfocitos T / Poliendocrinopatías Autoinmunes / Infecciones por Citomegalovirus / Citomegalovirus / Anticuerpos Antivirales Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Dinamarca
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Inmunoglobulina G / Linfocitos T / Poliendocrinopatías Autoinmunes / Infecciones por Citomegalovirus / Citomegalovirus / Anticuerpos Antivirales Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Dinamarca