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Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI.
Schönberg, Laura; Mohamed, Abdalla Z; Yu, Qiang; Kwiatek, Richard A; Del Fante, Peter; Calhoun, Vince D; Shan, Zack Y.
Afiliación
  • Schönberg L; Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
  • Mohamed AZ; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
  • Yu Q; Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
  • Kwiatek RA; Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
  • Del Fante P; Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
  • Calhoun VD; Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.
  • Shan ZY; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
J Cereb Blood Flow Metab ; : 271678X241270528, 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39113421
ABSTRACT
Neurological symptoms are central to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), yet its underlying neurophysiological mechanisms remain elusive. We examined a neglected aspect of task-based functional MRI, focusing on how blood oxygenation level-dependent (BOLD) signals alter during cognitive tasks in ME/CFS. This prospective observational study utilised MRI scans on ME/CFS participants and healthy controls (HCs) with sedentary lifestyles (ACTRN12622001095752). Participants completed two blocks of a Symbol Digit Modalities Test, with 30 trials per block split into two sets. The fMRI signal changes between blocks and sets were compared within and between groups. Thirty-four ME/CFS participants (38 years ± 10; 27 women) and 34 HCs (38 ± 10; 27 women), were evaluated. In the second task block, ME/CFS participants exhibited increased activation in the right postcentral gyrus, contrasting with decreased activation in multiple regions in HCs. These results were further confirmed by significantly higher bilateral dynamic changes (2nd vs 1st set) in the motor, sensory and cognitive cortex in ME/CFS compared to HCs and significant correlations between those changes in the left primary motor cortex with fatigue severities. BOLD adaptation, potentially improving energy economy, was absent in ME/CFS, which may provide an underlying neurophysiological process in ME/CFS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos