Your browser doesn't support javascript.
loading
Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes.
van der Horn, Harm Jan; Dodd, Andrew B; Wick, Tracey V; Robertson-Benta, Cidney; McQuaid, Jessica R; Erhardt, Erik B; Miller, Samuel D; Sasi Kumar, Divyasree; Nathaniel, Upasana; Ling, Josef M; Ryman, Sephira G; Vakhtin, Andrei A; Sapien, Robert E; Phillips, John P; Campbell, Richard A; Mayer, Andrew R.
Afiliación
  • van der Horn HJ; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Dodd AB; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Wick TV; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Robertson-Benta C; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • McQuaid JR; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Erhardt EB; Department of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.
  • Miller SD; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Sasi Kumar D; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Nathaniel U; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Ling JM; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Ryman SG; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Vakhtin AA; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Sapien RE; Department of Pediatric Emergency Medicine, University of New Mexico, Albuquerque, NM, USA.
  • Phillips JP; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
  • Campbell RA; Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.
  • Mayer AR; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
J Cereb Blood Flow Metab ; : 271678X241270531, 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39113416
ABSTRACT
Cerebrovascular dysfunction following mild traumatic brain injury (mTBI) is understudied relative to other microstructural injuries, especially during neurodevelopment. The blood-oxygen level dependent response was used to investigate cerebrovascular reactivity (CVR) in response to hypercapnia following pediatric mTBI (pmTBI; ages 8-18 years), as well as pseudocontinuous arterial spin labeling to measure cerebral blood flow (CBF). Data were collected ∼1-week (N = 107) and 4 months (N = 73) post-injury. Sex- and age-matched healthy controls (HC) underwent identical examinations at comparable time points (N = 110 and N = 91). Subtle clinical and cognitive deficits existed at ∼1 week that resolved for some, but not all domains at 4 months post-injury. At both visits, pmTBI showed an increased maximal fit between end-tidal CO2 regressor and the cerebrovascular response across multiple regions (primarily fronto-temporal), as well as increased latency to maximal fit in independent regions (primarily posterior). Hypoperfusion was also noted within the bilateral cerebellum. A biphasic relationship existed between CVR amplitude and age (i.e., positive until 14.5 years, negative thereafter) in both gray and white matter, but these neurodevelopment effects did not moderate injury effects. CVR metrics were not associated with post-concussive symptoms or cognitive deficits. In conclusion, cerebrovascular dysfunction may persist for up to four months following pmTBI.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos