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Induction of Cell Death by Bifidobacterium infantis DS1685 in Colorectal and Breast Cancers via SMAD4/TGF-Beta Activation.
Tae, In Hwan; Lee, Jinkwon; Kang, Yunsang; Lee, Jeong Min; Park, Kunhyang; Yang, Haneol; Kim, Hee-Won; Ko, Jeong Heon; Park, Doo-Sang; Kim, Dae-Soo; Son, Mi-Young; Cho, Hyun-Soo.
Afiliación
  • Tae IH; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Lee J; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Kang Y; Korea University of Science and Technology, Daejeon 34316, Republic of Korea.
  • Lee JM; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Park K; Korea University of Science and Technology, Daejeon 34316, Republic of Korea.
  • Yang H; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Kim HW; Korea University of Science and Technology, Daejeon 34316, Republic of Korea.
  • Ko JH; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Park DS; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Kim DS; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Son MY; Korea University of Science and Technology, Daejeon 34316, Republic of Korea.
  • Cho HS; Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
J Microbiol Biotechnol ; 34(8): 1698-1704, 2024 Aug 28.
Article en En | MEDLINE | ID: mdl-39113194
ABSTRACT
Therapeutic advancements in treatments for cancer, a leading cause of mortality worldwide, have lagged behind the increasing incidence of this disease. There is a growing interest in multifaceted approaches for cancer treatment, such as chemotherapy, targeted therapy, and immunotherapy, but due to their low efficacy and severe side effects, there is a need for the development of new cancer therapies. Recently, the human microbiome, which is comprised of various microorganisms, has emerged as an important research field due to its potential impact on cancer treatment. Among these microorganisms, Bifidobacterium infantis has been shown to significantly improve the efficacy of various anticancer drugs. However, research on the role of B. infantis in cancer treatment remains insufficient. Thus, in this study, we explored the anticancer effect of treatment with B. infantis DS1685 supernatant (BI sup) in colorectal and breast cancer cell lines. Treatment with BI sup induced SMAD4 expression to suppress cell growth in colon and breast cancer cells. Furthermore, a decrease in tumor cohesion was observed through the disruption of the regulation of EMT-related genes by BI sup in 3D spheroid models. Based on these findings, we anticipate that BI sup could play an adjunctive role in cancer therapy, and future cotreatment of BI sup with various anticancer drugs may lead to synergistic effects in cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Colorrectales / Factor de Crecimiento Transformador beta / Proteína Smad4 / Bifidobacterium longum subspecies infantis Límite: Female / Humans Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Colorrectales / Factor de Crecimiento Transformador beta / Proteína Smad4 / Bifidobacterium longum subspecies infantis Límite: Female / Humans Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur