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Barrier films or dressings for the prevention of acute radiation dermatitis in breast cancer: a systematic review and network meta-analysis.
Wong, Henry C Y; Lee, Shing Fung; Caini, Saverio; Chan, Adrian Wai; Kwan, Jennifer Y Y; Waddle, Mark; Sonis, Stephen; Herst, Patries; Alcorn, Sara; Bonomo, Pierluigi; Wong, Cindy; Corbin, Kimberly; Choi, J Isabelle; Rembielak, Agata; AlKhaifi, Muna; Marta, Gustavo Nader; Rades, Dirk; van den Hurk, Corina; Wolf, Julie Ryan; Chan, Raymond J; Schmeel, Leonard Christopher; Lock, Michael; Hijal, Tarek; Cao, Jeffrey; Kim, Hayeon; Chow, Edward.
Afiliación
  • Wong HCY; Department of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hospital Authority, Hong Kong S.A.R., China. henrywong3011@gmail.com.
  • Lee SF; Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
  • Caini S; Department of Clinical Oncology, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Kowloon, Hong Kong S.A.R., China.
  • Chan AW; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention, and Clinical Network (ISPRO), Florence, Italy.
  • Kwan JYY; Department of Clinical Oncology, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Kowloon, Hong Kong S.A.R., China.
  • Waddle M; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada.
  • Sonis S; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Herst P; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
  • Alcorn S; Division of Oral Medicine, Brigham and Women's Hospital and the Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bonomo P; Department of Radiation Therapy, University of Otago, Wellington, New Zealand.
  • Wong C; Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Corbin K; Department of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.
  • Choi JI; Union Oncology Centre, Kowloon, Hong Kong S.A.R., China.
  • Rembielak A; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
  • AlKhaifi M; New York Proton Center, New York, NY, USA.
  • Marta GN; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Rades D; Clinical Oncology Department, The Christie NHS Foundation Trust, Manchester, UK.
  • van den Hurk C; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
  • Wolf JR; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
  • Chan RJ; Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
  • Schmeel LC; Latin America Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.
  • Lock M; Department of Radiation Oncology, University of Lübeck, Luebeck, Germany.
  • Hijal T; Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
  • Cao J; Department of Dermatology, University of Rochester Medical Centre, Rochester, NY, USA.
  • Kim H; Department of Radiation Oncology, University of Rochester Medical Centre, Rochester, NY, USA.
  • Chow E; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.
Breast Cancer Res Treat ; 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39112742
ABSTRACT

BACKGROUND:

Barrier films or dressings were reported to be effective in preventing radiation dermatitis (RD) in breast cancer patients, but their comparative efficacy is unknown.

METHODS:

A systematic literature search was performed on Embase, MEDLINE and Cochrane CENTRAL Registry of Clinical Trials from inception to October 20, 2023. Randomised controlled trials (RCTs) comparing barrier films or dressings to the standard of care (SOC) or other interventions were included. We estimated summary odds ratios and mean differences using network meta-analysis with random effects. This study was registered with PROSPERO (ID CRD42023475021).

RESULTS:

Fourteen RCTs met inclusion criteria. Six interventions were analysed 3M™ Moisturizing Double Barrier Cream (MDBC), 3M™ No Sting Barrier Film (BF), Hydrofilm® (HF), Mepitel® Film (MF), Silver Leaf Nylon Dressing and StrataXRT®. HF, MF and StrataXRT® reduced the incidence of moist desquamation compared to SOC (HF OR = 0.08; p = 0.02; MF OR = 0.31 p < 0.01; StrataXRT® OR = 0.22, p = 0.04). The ranking of agents from most to least effective in preventing moist desquamation according to P-scores was HF (92.5%), MF (78.5%), StrataXRT® (70.1%), BF (46.4%), Silver Leaf Nylon Dressing (24.9%), MDBC (22.9%) and SOC (14.7%). Only four RCTs on HF and MF included patient-reported outcome (PRO) assessments that allowed pooling for analysis. HF and MF were more effective in reducing pain, itchiness and burning sensation compared to SOC (p < 0.01 for all symptoms).

CONCLUSION:

HF and MF were effective in preventing RD in breast cancer. Future RCTs should compare these interventions to effective cream preparations, such as topical corticosteroids.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Breast Cancer Res Treat Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Breast Cancer Res Treat Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos