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Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): Is it CIDP?
Burt, Richard K; Burman, Joachim; Barker, Alexander; Sharrack, Basil.
Afiliación
  • Burt RK; Department of Medicine, Scripps Health Care, La Jolla, CA, United States; Genani Corporation, Chicago, IL, United States. Electronic address: rburt@northwestern.edu.
  • Burman J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Barker A; Department of Clinical Neurophysiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
  • Sharrack B; Department of Neuroscience and Sheffield NIHR Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust and University of Sheffield, Sheffield, United Kingdom.
Handb Clin Neurol ; 202: 199-238, 2024.
Article en En | MEDLINE | ID: mdl-39111908
ABSTRACT
Autologous hematopoietic stem cell transplantation (HSCT) is associated with 5-year treatment-free remissions in approximately 80% of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who failed or were dependent on intravenous immunoglobulin and or plasmapheresis. Autologous HSCT was associated with significant improvement in strength, independent ambulation, quality of life, nerve conduction velocity, and compound muscle action potential amplitude. The results of HSCT are dependent on proper patient selection, i.e., the right diagnosis and the right stage of the disease. An important caveat is that a significant number of patients with a CIDP diagnostic label are found upon further workup have a peripheral neuropathy of another etiology. Patients undergoing HSCT for CIDP should be reevaluated before HSCT to confirm the diagnosis and those who fail HSCT should be reevaluated for a diagnosis other than CIDP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante Límite: Humans Idioma: En Revista: Handb Clin Neurol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante Límite: Humans Idioma: En Revista: Handb Clin Neurol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos