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Optic neuritis following COVID-19 vaccination: Case series and review of the literature.
Etemadifar, M; Nouri, H; Abtahi, S-H; Bathaei, R; Mardi, R; Salari, M; Dehghani, A; Panahi Seifabad, M; Jannesari, A.
Afiliación
  • Etemadifar M; Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Nouri H; Alzahra Research Institute, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; Ophthalmic Research Center, Research Institute for Ophthalmology, Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran; School of Medicine, Isfahan University of Me
  • Abtahi SH; Ophthalmic Research Center, Research Institute for Ophthalmology, Vision Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Bathaei R; Alzahra Research Institute, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mardi R; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Salari M; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Dehghani A; Isfahan Eye Research Center, Department of ophthalmology, Isfahan University of medical sciences, Isfahan, Iran.
  • Panahi Seifabad M; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Eye Research Center, Department of ophthalmology, Isfahan University of medical sciences, Isfahan, Iran.
  • Jannesari A; Alzahra Research Institute, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Ahmadreza.jannesari81@gmail.com.
J Fr Ophtalmol ; 47(8): 104264, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39111095
ABSTRACT

OBJECTIVE:

To review cases of optic neuritis after COVID-19 vaccination and add similar cases to the literature.

METHODS:

Thorough PubMed and Scopus searches were conducted, and data from studies describing optic neuritis after COVID-19 vaccination were extracted, tabulated, pooled, and reviewed.

RESULTS:

We present 6 cases of optic neuritis following COVID-19 vaccination. Our literature search yielded 48 similar cases. All 54 cases were divided into 3 groups with respect to their serostatus (1) double-seronegative or unknown serostatus optic neuritis cases, (2) myelin oligodendrocyte glycoprotein (MOG)-associated optic neuritis cases, and (3) aquaporin-4-associated optic neuritis cases. Data from each group were separately pooled and reviewed. While the most frequent vaccine among the anti-AQP4+ subgroup was BNT162b2 (Pfizer-BioNTech) (2/3), recombinant vaccines, e.g., AZD122 and Ad26.Cov2.s were mostly injected in the other subgroups (23/51). No significant gender inclination was seen among different subgroups. The mean interval from vaccination to symptom onset was less than one month in all subgroups; symptom manifestations mainly occurred after the first dose (28/54). Almost all cases showed improvement after steroid therapy±plasma exchange (52/54).

CONCLUSION:

Despite having rare side effects such as optic neuritis, vaccination remains our most helpful protection against SARS-CoV-2. Nevertheless, larger studies are needed to ascertain the pathophysiology of such adverse effects. Likewise, the association between COVID-19 vaccination and optic neuritis warrants further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuritis Óptica / Vacunas contra la COVID-19 / COVID-19 Límite: Humans Idioma: En Revista: J Fr Ophtalmol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuritis Óptica / Vacunas contra la COVID-19 / COVID-19 Límite: Humans Idioma: En Revista: J Fr Ophtalmol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia