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Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men.
DuBose, Lyndsey E; Babcock, Matthew C; Kohrt, Wendy M; Stauffer, Brian L; Hildreth, Kerry L; Walker, Jacob; Armstrong, Matthew K; Moreau, Kerrie L.
Afiliación
  • DuBose LE; Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
  • Babcock MC; Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
  • Kohrt WM; Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
  • Stauffer BL; Veterans Affairs Eastern Colorado Geriatric Research, Educational and Clinical Center (GRECC), Aurora, CO, USA.
  • Hildreth KL; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Walker J; Division of Cardiology, Denver Health Medical Center, Denver, CO, USA.
  • Armstrong MK; Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
  • Moreau KL; Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
Geroscience ; 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39110324
ABSTRACT
Hypogonadism is a risk factor for cardiovascular disease (CVD) in men related, in part, to increased oxidative stress. Elevated large artery stiffness and central pulsatile hemodynamics (e.g., pulse pressure and wave reflection magnitude) are independent risk factors for CVD. However, whether large artery stiffness and central pulsatile hemodynamics are (1) elevated in hypogonadal men independent of traditional CVD risk factors and (2) related to increased oxidative stress is unknown. Young men (N = 23; 30 ± 4 years) and middle-aged/older (MA/O) men with normal (> 400-1000 ng/dL; n = 57; 59 ± 7 years) or low testosterone (< 300 ng/dL; n = 21; 59 ± 7 years) underwent assessments of large artery stiffness (carotid ß-stiffness via ultrasonography) and central pulsatile hemodynamics (pulse wave analysis; SphygmoCor XCEL) following an infusion of saline or vitamin C to test the tonic suppression of vascular function by oxidative stress. Carotid stiffness differed by age (p < 0.001) and gonadal status within MA/O men (low testosterone vs. normal testosterone 9.3 ± 0.7 vs. 8.0 ± 0.3U, p = 0.036). Central pulsatile hemodynamics did not differ by age or gonadal status (p > 0.119). Vitamin C did not alter carotid stiffness in any group (p > 0.171). There was a significant group × infusion interaction on aortic reflection magnitude (p = 0.015). Vitamin C treatment reduced aortic reflection magnitude in young and MA/O men with normal testosterone (both p < 0.001) but not MA/O men with low testosterone (p = 0.891). Collectively, hypogonadism may accelerate age-related large artery stiffening in MA/O men with low testosterone, independent of CVD risk factors; however, this is not related to increased reactive oxygen species sensitive to an acute vitamin C infusion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza