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Levosimendan: A New Therapeutical Strategy in Patients with Renal Insufficiency.
Liu, Xinwen; Lu, Mengkai; Yu, Yanna; Shen, Nannan; Xia, Haijiang; Shi, Jiana; Fu, Yongping; Hu, Ying.
Afiliación
  • Liu X; Department of Pharmacy, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
  • Lu M; Department of Pharmacy, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
  • Yu Y; Department of Pharmacy, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
  • Shen N; Department of Pharmacy, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
  • Xia H; Department of Cardiovascular Medicine, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
  • Shi J; Clinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
  • Fu Y; Department of Cardiovascular Medicine, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China. fuyongping@usx.edu.cn.
  • Hu Y; Clinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China. huying@hmc.edu.cn.
Cardiovasc Drugs Ther ; 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39110308
ABSTRACT
Levosimendan, a Ca2 + sensitizer with positive inotropic effects, is primarily employed for the short-term treatment of acute decompensated heart failure (ADHF). Levosimendan exerts renal function protection through various mechanisms, including anti-apoptosis, anti-inflammatory, and antioxidant effects in vivo. Additionally, levosimendan may have a protective effect on individuals with heart failure and renal insufficiency, as well as on renal function impairment after cardiac surgery. However, the application of levosimendan in patients with severe renal dysfunction remains controversial. This article delves into the use of levosimendan in severe renal insufficiency, explores its impact on renal function, and provides a comprehensive overview of its impact on renal function after cardiac surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiovasc Drugs Ther Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiovasc Drugs Ther Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos