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Porphyrin Production by Corynebacterium diphtheriae Strains from Clinical Isolates.
Alves, Gabriela Batista; da Costa Marques Calderari, Mônica Regina; da Fonseca, Eduardo Nunes; Dos Santos, Louisy Sanches; de Mattos-Guaraldi, Ana Luiza.
Afiliación
  • Alves GB; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Rio de Janeiro State University, Av. 28 de Setembro, 87 - Fundos, 3° andar, Vila Isabel, RJ, CEP 20 551-030, Brazil.
  • da Costa Marques Calderari MR; General and Inorganic Chemistry Laboratory, Federal Institute of Education, Science and Technology of Rio de Janeiro, Rua Senador Furtado, 121, Maracanã, Rio de Janeiro, RJ, CEP 20270-021, Brazil.
  • da Fonseca EN; Analytical Center Fernanda Coutinho, Rio de Janeiro State University, R. São Francisco Xavier, 524 - Maracanã, Rio de Janeiro, RJ, CEP 20550-013, Brazil.
  • Dos Santos LS; Analytical Center Fernanda Coutinho, Rio de Janeiro State University, R. São Francisco Xavier, 524 - Maracanã, Rio de Janeiro, RJ, CEP 20550-013, Brazil.
  • de Mattos-Guaraldi AL; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Rio de Janeiro State University, Av. 28 de Setembro, 87 - Fundos, 3° andar, Vila Isabel, RJ, CEP 20 551-030, Brazil.
Chem Biodivers ; : e202401011, 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39110090
ABSTRACT
Porphyrins are intermediate metabolites involved in the biosynthesis of vital molecules, including heme, cobalamin, and chlorophyll. Bacterial porphyrins are known to be proinflammatory and are associated with biofilm formation. This study investigated porphyrin production by strains of Corynebacterium diphtheriae using emission spectroscopy, high-performance liquid chromatography with fluorescence detection, diode array detector, and mass spectrometry. Emission spectroscopy revealed characteristic porphyrin emission spectra in all strains, with coproporphyrin III predominating. Qualitative analysis by different chromatographic methods identified coproporphyrin III, uroporphyrin I, and protoporphyrin IX in all strains. Quantitative analysis revealed strain-dependent coproporphyrin III production. Further studies are required to investigate the relationship between porphyrin production and the virulence potential of Corynebacterium diphtheriae.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza