Aminopyridines in the development of drug candidates against protozoan neglected tropical diseases.
Future Med Chem
; 16(13): 1357-1373, 2024 Jul 02.
Article
en En
| MEDLINE
| ID: mdl-39109436
ABSTRACT
Neglected tropical diseases (NTDs) pose a major threat in tropical zones for impoverished populations. Difficulty of access, adverse effects or low efficacy limit the use of current therapeutic options. Therefore, development of new drugs against NTDs is a necessity. Compounds containing an aminopyridine (AP) moiety are of great interest for the design of new anti-NTD drugs due to their intrinsic properties compared with their closest chemical structures. Currently, over 40 compounds with an AP moiety are on the market, but none is used against NTDs despite active research on APs. The aim of this review is to present the medicinal chemistry work carried out with these scaffolds, against protozoan NTDs Trypanosoma cruzi, Trypanosoma brucei or Leishmania spp.
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Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trypanosoma brucei brucei
/
Trypanosoma cruzi
/
Enfermedades Desatendidas
/
Aminopiridinas
/
Antiprotozoarios
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido