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Effects of Singing on Vascular Health in Older Adults with Coronary Artery Disease: A Randomized Trial.
Bagherimohamadipour, Mehri; Hammad, Muhammad; Visotcky, Alexis; Sparapani, Rodney; Kulinski, Jacquelyn.
Afiliación
  • Bagherimohamadipour M; Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI.
  • Hammad M; Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI.
  • Visotcky A; Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
  • Sparapani R; Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
  • Kulinski J; Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI.
medRxiv ; 2024 Jul 27.
Article en En | MEDLINE | ID: mdl-39108506
ABSTRACT

Background:

The impact of singing on cardiovascular health has not been extensively studied. The aim of this study is to investigate the effect of singing on cardiovascular biomarkers in an aging population with coronary artery disease.

Methods:

Participants had three study visits separated by 2-7 days, according to a randomized, single-blind, cross-over, controlled

design:

(1) a 30-minute period of coached singing from an in-person music therapist, (2) a 30-minute period of singing along to an instructional video and (3) a 30-minute rest (control). Primary outcomes included macrovascular endothelial function assessed by brachial artery flow-mediated dilation and microvascular function assessed by peripheral arterial tonometry (Framingham reactive hyperemia index; fRHI). Heart rate variability was a secondary outcome.

Results:

Sixty-five subjects (mean age 67.7± 0.8, 40% women) completed the study. Compared to control, there was an increase in fRHI for the singing video intervention (estimate 0.54, SE 0.25, p=0.005) but not for the coaching intervention (estimate 0.11, SE 0.18, p=0.570). There was no change in macrovascular function with either intervention. The low frequency/high frequency (LF/HF) ratio increased by 2.80 (SE 1.03, p=0.008), and the LnHF power decreased by -0.90 ms2 (SE 0.29, p=0.003) with the video (during to pre-change). When assessing post- to pre- change, the coaching intervention showed a significant change of -0.62 ms2 (SE 0.29, p=0.036) in LnHF power.

Conclusions:

Singing along to an instructional video for 30 minutes improved microvascular, but not macrovascular, endothelial function, in older patients with CAD. HRV changes with singing are similar to that of exercise. Clinical trial registration ClinicalTrials.gov, identifier NCT04121741.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos