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Room temperature synthesis of a chiral covalent organic framework core-shell composite for high-performance liquid chromatography enantioseparation.
Zhang, Yue; Lu, Yan-Rui; Liu, Cheng; Ma, An-Xu; Luo, Zong-Hong; Zhou, Hong-Mei; Zhang, Jun-Hui; Wang, Bang-Jin; Xie, Sheng-Ming; Yuan, Li-Ming.
Afiliación
  • Zhang Y; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Lu YR; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Liu C; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Ma AX; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Luo ZH; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Zhou HM; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Zhang JH; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Wang BJ; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Xie SM; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
  • Yuan LM; Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
J Sep Sci ; 47(15): e2400140, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39108164
ABSTRACT
In this article, chiral covalent organic framework core-shell composite CCOF-TpPa-Py@SiO2 was facilely synthesized by induction at room temperature. The CCOF-TpPa-Py@SiO2 core-shell composite was used as a chiral stationary phase for the separation of the racemates by high-performance liquid chromatography, which exhibits good separation performance for chiral compounds including ketones, alcohols, esters, epoxides, carboxylic acids, amides, and amines. The effects of analyte injection mass on the enantioseparation were studied. The reproducibility and stability of the CCOF-TpPa-Py@SiO2 chiral column were explored. The intra-day (n = 5), inter-day (n = 5), and inter-column (n = 3) relative standard deviations for the migration times and resolution of benzoin were 0.32%-0.54%, 0.45%-0.61%, and 1.21%-1.53%, respectively. In addition, the chiral separation ability of the CCOF-TpPa-Py@SiO2 chiral column (column A) was compared with that of the MDI-ß-CD-Modified COF@SiO2 (column B) as well as a commercial chiral column (Chiralpak AD-H). The chiral recognition ability of column A is complementary to that of column B and AD-H column. The resolution mechanism of CCOF-TpPa-Py@SiO2 stationary phase towards chiral analyte was explored. Hence, the synthesis of CCOF-TpPa-Py@SiO2 core-shell composite by induction at room temperature as chiral stationary phases for chromatographic separation has important research potential and application prospects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Sep Sci Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Sep Sci Año: 2024 Tipo del documento: Article Pais de publicación: Alemania