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Comparison of Thermal and Mechanical Pain Testing Modalities in Sprague Dawley and Fischer 344 Rats (Rattus norvegicus).
McNew, James F; Davis, Daniel J; Grimsrud, Kristin N; Bryda, Elizabeth C.
Afiliación
  • McNew JF; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Comparative Medicine Program, University of Missouri, Columbia, Missouri.
  • Davis DJ; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Comparative Medicine Program, University of Missouri, Columbia, Missouri; Animal Modeling Core, University of Missouri, Columbia, Missouri.
  • Grimsrud KN; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California; Mouse Biology Program, University of California, Davis, Davis, California.
  • Bryda EC; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Comparative Medicine Program, University of Missouri, Columbia, Missouri; Animal Modeling Core, University of Missouri, Columbia, Missouri; Rat Resource and Research Center, University
Comp Med ; 74(3): 173-178, 2024 Jun 01.
Article en En | MEDLINE | ID: mdl-39107939
ABSTRACT
While rodents are used extensively for studying pain, there is a lack of reported direct comparisons of thermal and mechanical pain testing methods in rats of different genetic backgrounds. Understanding the range of interindividual variability of withdrawal thresholds and thermal latencies based on these testing methods and/or genetic background is important for appropriate experimental design. Testing was performed in two common rat genetic backgrounds outbred Sprague-Dawley (SD) and inbred Fischer 344 (F344). Male and female, 10- to 14-wk-old F344 and SD rats were used to assess withdrawal thresholds in 3 different modalities the Randall-Selitto test (RST), Hargreaves test (HT), and tail flick test (TFT). The RST was performed by using an operator-controlled handheld instrument to generate a noxious pressure stimulus to the left hind paw. The HT and the TFT used an electronically controlled light source to deliver a noxious thermal stimulus to the left hind paw or tail tip, respectively. Rats of each sex and genetic background underwent one type of test on day 0 and day 7. Withdrawal thresholds and thermal latencies were compared among tests. No significant differences were observed. Our findings can serve as a guide for researchers considering these nociceptive tests for their experiments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas Endogámicas F344 / Dimensión del Dolor / Ratas Sprague-Dawley / Umbral del Dolor / Calor Límite: Animals Idioma: En Revista: Comp Med Asunto de la revista: MEDICINA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas Endogámicas F344 / Dimensión del Dolor / Ratas Sprague-Dawley / Umbral del Dolor / Calor Límite: Animals Idioma: En Revista: Comp Med Asunto de la revista: MEDICINA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos