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Effects and Action Mode of Oleic Acid and Azone on Release and Penetration Process of Levothyroxine Sodium Patches.
Li, Xing; Liang, Kaili; Dong, Yingying; Li, Shen; Gao, Zhengnan; Wang, Qing.
Afiliación
  • Li X; Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, P. R. China.
  • Liang K; Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, P. R. China.
  • Dong Y; Central Hospital affiliated to University of Science and Technology, Dalian, 116021, P. R. China.
  • Li S; Central Hospital affiliated to University of Science and Technology, Dalian, 116021, P. R. China.
  • Gao Z; Central Hospital affiliated to University of Science and Technology, Dalian, 116021, P. R. China. gao2008@dlut.edu.cn.
  • Wang Q; Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, P. R. China. qwang@dlut.edu.cn.
AAPS PharmSciTech ; 25(6): 180, 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39107558
ABSTRACT
In recent years, there has been a significant increase in the prevalence of thyroid diseases, particularly hypothyroidism. In this study, we investigated the impact and mechanisms of Chemical permeation enhancement(CPE) on transdermal permeation of levothyroxine sodium (L-T4) patches.We found that the combination of oleic acid (OA) and Azone (NZ) yielded the best transdermal permeation effect for L-T4.Subsequently, we also investigated the relevant propermeability mechanism.The results demonstrate that the combined application of OA and NZ significantly enhances the transdermal permeation of L-T4 compared to individual applications,it is attributed to two mechanisms firstly, OA improves drug release by increasing the flowability of the pressure-sensitive adhesive (PSA) matrix; secondly, both OA and NZ act on the stratum corneum, especially facilitating L-T4 permeation through the hair follicle pathway. No skin irritation or cytotoxicity is observed with these final patches, which exhibit a remarkable therapeutic effect on hypothyroidism. this study contributes to the development of transdermal formulations of L-T4.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Absorción Cutánea / Tiroxina / Administración Cutánea / Ácido Oléico Límite: Animals / Humans / Male Idioma: En Revista: AAPS PharmSciTech Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Absorción Cutánea / Tiroxina / Administración Cutánea / Ácido Oléico Límite: Animals / Humans / Male Idioma: En Revista: AAPS PharmSciTech Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos