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DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression.
Shao, Lan; Yu, Haoran; Wang, Mengyun; Chen, Lu; Ji, Boshu; Wu, Tong; Teng, Xiangqi; Su, Mu; Han, Xiao; Shi, Weikai; Hu, Xin; Wang, Ziwen; He, Hongjuan; Han, Guiping; Zhang, Yan; Wu, Qiong.
Afiliación
  • Shao L; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Yu H; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Wang M; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Chen L; Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Ji B; Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Wu T; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Teng X; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Su M; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Han X; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Shi W; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Hu X; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Wang Z; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • He H; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Han G; Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zhang Y; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
  • Wu Q; School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China. kigo@hit.edu.cn.
Cell Death Dis ; 15(8): 566, 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39107271
ABSTRACT
Super-enhancers are a class of DNA cis-regulatory elements that can regulate cell identity, cell fate, stem cell pluripotency, and even tumorigenesis. Increasing evidence shows that epigenetic modifications play an important role in the pathogenesis of various types of cancer. However, the current research is far from enough to reveal the complex mechanism behind it. This study found a super-enhancer enriched with abnormally active histone modifications in pancreatic ductal adenocarcinoma (PDAC), called DKK1-super-enhancer (DKK1-SE). The major active component of DKK1-SE is component enhancer e1. Mechanistically, AP1 induces chromatin remodeling in component enhancer e1 and activates the transcriptional activity of DKK1. Moreover, DKK1 was closely related to the malignant clinical features of PDAC. Deletion or knockdown of DKK1-SE significantly inhibited the proliferation, colony formation, motility, migration, and invasion of PDAC cells in vitro, and these phenomena were partly mitigated upon rescuing DKK1 expression. In vivo, DKK1-SE deficiency not only inhibited tumor proliferation but also reduced the complexity of the tumor microenvironment. This study identifies that DKK1-SE drives DKK1 expression by recruiting AP1 transcription factors, exerting oncogenic effects in PDAC, and enhancing the complexity of the tumor microenvironment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Factor de Transcripción AP-1 / Progresión de la Enfermedad / Péptidos y Proteínas de Señalización Intercelular / Proliferación Celular Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Death Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Factor de Transcripción AP-1 / Progresión de la Enfermedad / Péptidos y Proteínas de Señalización Intercelular / Proliferación Celular Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Death Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido