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Cerebral Hypoxia-Induced Molecular Alterations and Their Impact on the Physiology of Neurons and Dendritic Spines: A Comprehensive Review.
Cui, Chao; Jiang, Xue; Wang, Yumei; Li, Chao; Lin, Zhaochen; Wei, Youzhen; Ni, Qingbin.
Afiliación
  • Cui C; Hydrogen Medical Research Center, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China.
  • Jiang X; Hydrogen Medical Research Center, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China.
  • Wang Y; Hydrogen Medical Research Center, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China.
  • Li C; Hydrogen Medical Research Center, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China.
  • Lin Z; Hydrogen Medical Research Center, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China.
  • Wei Y; Hydrogen Medical Research Center, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China. wei-youzhen@163.com.
  • Ni Q; Research Center for Translational Medicine & Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200000, China. wei-youzhen@163.com.
Cell Mol Neurobiol ; 44(1): 58, 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39105862
ABSTRACT
This article comprehensively reviews how cerebral hypoxia impacts the physiological state of neurons and dendritic spines through a series of molecular changes, and explores the causal relationship between these changes and neuronal functional impairment. As a severe pathological condition, cerebral hypoxia can significantly alter the morphology and function of neurons and dendritic spines. Specifically, dendritic spines, being the critical structures for neurons to receive information, undergo changes such as a reduction in number and morphological abnormalities under hypoxic conditions. These alterations further affect synaptic function, leading to neurotransmission disorders. This article delves into the roles of molecular pathways like MAPK, AMPA receptors, NMDA receptors, and BDNF in the hypoxia-induced changes in neurons and dendritic spines, and outlines current treatment strategies. Neurons are particularly sensitive to cerebral hypoxia, with their apical dendrites being vulnerable to damage, thereby affecting cognitive function. Additionally, astrocytes and microglia play an indispensable role in protecting neuronal and synaptic structures, regulating their normal functions, and contributing to the repair process following injury. These studies not only contribute to understanding the pathogenesis of related neurological diseases but also provide important insights for developing novel therapeutic strategies. Future research should further focus on the dynamic changes in neurons and dendritic spines under hypoxic conditions and their intrinsic connections with cognitive function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espinas Dendríticas / Neuronas Límite: Animals / Humans Idioma: En Revista: Cell Mol Neurobiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espinas Dendríticas / Neuronas Límite: Animals / Humans Idioma: En Revista: Cell Mol Neurobiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos