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Associations of different inflammatory factors with atherosclerosis among patients with psoriasis vulgaris.
Huong, Nguyen Thi Kim; Long, Bui; Doanh, Le Huu; Thoai, Tran Minh; Hang, Nguyen Thi; Khoi, Le; Nu, Pham Thi.
Afiliación
  • Huong NTK; Hanoi Medical University, Hanoi, Vietnam.
  • Long B; Department of Dermatology, Friendship Hospital, Hanoi, Vietnam.
  • Doanh LH; Department of Interventional Cardiology, Friendship Hospital, Hanoi, Vietnam.
  • Thoai TM; National Dermatology Hospital, Hanoi, Vietnam.
  • Hang NT; Department of Interventional Cardiology, Friendship Hospital, Hanoi, Vietnam.
  • Khoi L; Department of Interventional Cardiology, Friendship Hospital, Hanoi, Vietnam.
  • Nu PT; Department of Interventional Cardiology, Friendship Hospital, Hanoi, Vietnam.
Front Med (Lausanne) ; 11: 1396680, 2024.
Article en En | MEDLINE | ID: mdl-39104857
ABSTRACT

Background:

This study aimed to measure the associations between different inflammatory factors, namely interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and high-sensitivity C-reactive protein (hs-CRP), and atherosclerosis in patients with psoriasis vulgaris.

Methods:

A cross-sectional study was conducted at two hospitals in Hanoi, Vietnam. A total of 125 patients with psoriasis vulgaris and 50 healthy controls were recruited. Clinical characteristics and atherosclerosis were assessed. IL-17A, TNF-α, and hs-CRP levels were measured.

Results:

Psoriasis vulgaris patients with atherosclerosis had higher levels of hs-CRP (median = 1.22; interquartile range-IQR = 0.34-12.11) and IL-17A (median = 1.30; IQR = 0.43-4.28), but a lower level of TNF-α (median = 0.54; IQR = 0.13-3.41) compared to those without atherosclerosis (p < 0.05). Only LogIL-17A was positively related to atherosclerosis in psoriasis patients (Odds Ratio-OR = 2.16, 95% CI = 1.06-4.38, p < 0.05). After excluding systemically treated patients, LogIL-17A and Log TNF-α were associated with the likelihood of atherosclerosis (p < 0.05).

Conclusion:

This study suggests a link between elevated levels of IL-17A and TNF-α and subclinical atherosclerosis. Further investigation on a larger scale is required to establish the causality of this relationship.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza