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Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment.
Teles, Flavia R F; Chandrasekaran, Ganesh; Martin, Lynn; Patel, Michele; Kallan, Michael J; Furquim, Camila; Hamza, Tahir; Cucchiara, Andrew J; Kantarci, Alpdogan; Urquhart, Olivia; Sugai, James; Giannobile, William V.
Afiliación
  • Teles FRF; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Chandrasekaran G; Center for Innovation and Precision Dentistry (CiPD), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Martin L; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Patel M; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kallan MJ; Multiplex Core, The Forsyth Institute, Cambridge, Massachusetts, USA.
  • Furquim C; Center for Clinical Epidemiology and Biostatistics (CCEB), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Hamza T; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Cucchiara AJ; Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos, São Paulo, Brazil.
  • Kantarci A; Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Urquhart O; Center for Clinical Epidemiology and Biostatistics (CCEB), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Sugai J; Multiplex Core, The Forsyth Institute, Cambridge, Massachusetts, USA.
  • Giannobile WV; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
J Clin Periodontol ; 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-39104016
ABSTRACT

AIM:

To identify serum- and salivary-derived inflammatory biomarkers of periodontitis progression and determine their response to non-surgical treatment. MATERIALS AND

METHODS:

Periodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi-monthly for 1 year without therapy. Periodontitis patients were re-examined 6 months after non-surgical periodontal therapy (NSPT). Participants were classified according to disease progression P0 (no sites progressed; P1 1-2 sites progressed; P2 3 or more sites progressed). Ten salivary and five serum biomarkers were measured using Luminex. Log-transformed levels were compared over time according to baseline diagnosis, progression trajectory and after NSPT. Significant differences were sought using linear mixed models.

RESULTS:

P2 presented higher levels (p < .05) of salivary IFNγ, IL-6, VEGF, IL-1ß, MMP-8, IL-10 and OPG over time. Serum analytes were not associated with progression. NSPT led to clinical improvement and significant reduction of IFNγ, IL-6, IL-8, IL-1ß, MMP-8, IL-10, OPG and MMP-9 in saliva and of CRP, MMP-8, MMP-9 and MPO in serum.

CONCLUSIONS:

Periodontitis progression results from a sustained pro-inflammatory milieu that is reflected in salivary biomarkers, but less so in serum, likely because of the limited amount of progression per patient. NSPT can significantly decrease the levels of several salivary analytes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Periodontol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Periodontol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos