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Harnessing immunomodulation to combat sarcopenia: current insights and possible approaches.
Zhang, Ning; Zhai, Liting; Wong, Ronald Man Yeung; Cui, Can; Law, Sheung-Wai; Chow, Simon Kwoon-Ho; Goodman, Stuart B; Cheung, Wing-Hoi.
Afiliación
  • Zhang N; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China. ningzhang@cuhk.edu.hk.
  • Zhai L; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. ningzhang@cuhk.edu.hk.
  • Wong RMY; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Cui C; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
  • Law SW; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
  • Chow SK; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Goodman SB; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
  • Cheung WH; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Immun Ageing ; 21(1): 55, 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-39103919
ABSTRACT
Sarcopenia is a complex age-associated syndrome of progressive loss of muscle mass and strength. Although this condition is influenced by many factors, age-related changes in immune function including immune cell dynamics, and chronic inflammation contribute to its progression. The complex interplay between the immune system, gut-muscle axis, and autophagy further underscores their important roles in sarcopenia pathogenesis. Immunomodulation has emerged as a promising strategy to counteract sarcopenia. Traditional management approaches to treat sarcopenia including physical exercise and nutritional supplementation, and the emerging technologies of biophysical stimulation demonstrated the importance of immunomodulation and regulation of macrophages and T cells and reduction of chronic inflammation. Treatments to alleviate low-grade inflammation in older adults by modulating gut microbial composition and diversity further combat sarcopenia. Furthermore, some pharmacological interventions, nano-medicine, and cell therapies targeting muscle, gut microbiota, or autophagy present additional avenues for immunomodulation in sarcopenia. This narrative review explores the immunological underpinnings of sarcopenia, elucidating the relationship between the immune system and muscle during ageing. Additionally, the review discusses new areas such as the gut-muscle axis and autophagy, which bridge immune system function and muscle health. Insights into current and potential approaches for sarcopenia management through modulation of the immune system are provided, along with suggestions for future research directions and therapeutic strategies. We aim to guide further investigation into clinical immunological biomarkers and identify indicators for sarcopenia diagnosis and potential treatment targets to combat this condition. We also aim to draw attention to the importance of considering immunomodulation in the clinical management of sarcopenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Immun Ageing Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Immun Ageing Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido