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The effects of nonsoy legumes consumption on serum levels of inflammatory biomarkers and Adiponectin in overweight/obese adults: A systematic review and meta-analysis of randomized controlled trials.
Mansouri, Fatemeh; de Simone, Gaia; Bordoni, Laura; Gabbianelli, Rosita.
Afiliación
  • Mansouri F; School of Advanced Studies, University of Camerino, Camerino, Macerata, Italy; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy and Health Products, University of Camerino, Camerino, Macerata, Italy.
  • de Simone G; School of Advanced Studies, University of Camerino, Camerino, Macerata, Italy; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy and Health Products, University of Camerino, Camerino, Macerata, Italy.
  • Bordoni L; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy and Health Products, University of Camerino, Camerino, Macerata, Italy. Electronic address: laura.bordoni@unicam.it.
  • Gabbianelli R; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy and Health Products, University of Camerino, Camerino, Macerata, Italy. Electronic address: rosita.gabbianelli@unicam.it.
J Nutr Biochem ; 133: 109718, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39103105
ABSTRACT
Nonsoy legumes offer many health benefits, including improved arterial function, reduced cholesterol levels, and better management of cardiovascular diseases and type 2 diabetes. This systematic review and meta-analysis aim to clarify the inconclusive findings from randomized controlled trials (RCTs) by comprehensively evaluating the effects of nonsoy legumes consumption on serum levels of inflammatory biomarkers and Adiponectin. The search encompassed databases up to January 2024, including PubMed, EMBASE, MEDLINE, Scopus, Web of Science, and Cochrane CENTRAL to retrieve all RCTs examining the effects of nonsoy legumes on inflammatory biomarkers or Adiponectin. The effect sizes quantified as mean differences (MD) and standard deviations (SD) of outcomes, and an overall effect estimate was derived using a random-effects model. RCTs examining serum levels of C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1ß (IL-1ß), and Adiponectin were included in the final meta-analysis. Results revealed that consumption of nonsoy legumes increased Adiponectin serum levels (P=.0017) and reduced IL-1ß serum levels (P<.0001). However, it may not significantly affect CRP (P=.2951), IL-6 (P=.2286), and TNF-α (P=.6661) levels. Subgroup analyses showed that nonsoy legumes consumption significantly decreased TNF-α serum levels in studies involving healthy participants. Additionally, sensitivity analysis using the leave-one-out method suggested a potential significant reduction in serum levels of IL-6. This study indicates that consuming nonsoy legumes can increase levels of Adiponectin and decrease serum levels of IL-1ß in overweight or obese adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Ensayos Clínicos Controlados Aleatorios como Asunto / Sobrepeso / Adiponectina / Fabaceae / Obesidad Límite: Adult / Humans Idioma: En Revista: J Nutr Biochem Asunto de la revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Ensayos Clínicos Controlados Aleatorios como Asunto / Sobrepeso / Adiponectina / Fabaceae / Obesidad Límite: Adult / Humans Idioma: En Revista: J Nutr Biochem Asunto de la revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos