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MicroRNA profiles in Zika virus infection: Insights from diverse sources.
Mousavi, Mohammad Javad; Arefinia, Nasir; Azarsa, Mohammad; Hoseinnezhad, Taraneh; Behboudi, Emad.
Afiliación
  • Mousavi MJ; Department of Hematology, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: m.j.mousavi@bpums.ac.ir.
  • Arefinia N; Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran. Electronic address: n.arefinia@gmail.com.
  • Azarsa M; Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran.
  • Hoseinnezhad T; Department of Hematology, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: aliemadi41@yahoo.com.
  • Behboudi E; Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran. Electronic address: emadbehboudi69@gmail.com.
Indian J Med Microbiol ; 51: 100697, 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-39103054
ABSTRACT

BACKGROUND:

Zika virus (ZIKV) stands as one of the most significant reemerging viral pathogens, linked to neurological diseases such as meningoencephalitis and congenital microcephaly. Today there are no effective therapies for treating ZIKV-infected patients. MiRNAs play a critical role in regulating cellular signaling and physiological conditions, and alterations in their profiles can bear great significance in disease progression.

OBJECTIVES:

Despite significant progress in understanding the interaction between the ZIKV and its host since the outbreak, a more comprehensive understanding on these interactions is imperative. This review aims to summarize the studies in the field and shed light on the intricate relationship between ZIKV and its host at the molecular level. CONTENT We found that in ZIKV-infected humans, over-expression of miR-431-5p and miR-30e-5p plays a crucial role in innate immune responses and contributes to neurological damage. Additionally, in ZIKA-infected mice, we observed upregulated expression of all the targets of miR-124-3p including CCL2, IL7, IRF1, and SBNO2. Notably, other targets of this miRNA include TLR6, TNF, STAT3, and NF-kB also exhibited upregulation in the central nervous system (CNS) of infected mice. Conversely, miR-654-3p levels were reduced, correlating with the upregulation of its predicted targets including FLT3LG, LITAF, CD69, and TLR2. In the case of insects, aae-miR-286a/b-3p was predicted to target all ZIKV genotypes. This specific miRNA is typically found in ovaries and can be transferred to embryos. In conclusion, our findings suggest that host microRNAs and ZIKV-encoded microRNAs hold promise as potential targets for the diagnosis of ZIKV infections and may even serve as a therapeutic approach for managing this infectious disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos