Your browser doesn't support javascript.
loading
Oleate alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 release.
Cole-Skinner, Breanna; Andre, Nicole M; Blankenheim, Zachary; Root, Kate M; Jafri, Kisa; Simmons, Glenn E.
Afiliación
  • Cole-Skinner B; Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, United States.
  • Andre NM; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
  • Blankenheim Z; Department of Biomedical Sciences, School of Medicine, University of Minnesota, Duluth, United States.
  • Root KM; Department of Biomedical Sciences, School of Medicine, University of Minnesota, Duluth, United States.
  • Jafri K; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
  • Simmons GE; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Front Cell Dev Biol ; 12: 1348707, 2024.
Article en En | MEDLINE | ID: mdl-39100092
ABSTRACT

Background:

Cancer cell evasion of the immune response is critical to cancer development and metastases. Clinicians' ability to kickstart the immune system to target these rogue cells is an ever-growing area of research and medicine. This study delved into the relationship between lipid metabolism, High Mobility Group Box 1 protein (HMGB1)-a pro-inflammatory damage-associated molecular pattern protein-and immune regulation within non-small cell lung adenocarcinoma (NSCLC).

Method:

To address this question, we used a combination of proteomics, molecular biology, and bioinformatic techniques to investigate the relationship between fatty acids and immune signals within NSCLC.

Results:

We found that the expression of stearoyl CoA desaturase 1 (SCD1) was decreased in NSCLC tumors compared to normal tissues. This emphasized the critical role of lipid metabolism in tumor progression. Interestingly, monounsaturated fatty acid (MUFA) availability affected the expression of programmed death ligand-1 (PD-L1), a pivotal immune checkpoint target in lung cancer cells and immune cells, as well as HMGB1, suggesting a novel approach to modulating the immune response. This study uncovered a complex interplay between SCD1, PD-L1, and HMGB1, influencing the immunological sensitivity of tumors.

Conclusion:

Our work underscores the critical importance of understanding the intricate relationships between lipid metabolism and immune modulation to develop more effective NSCLC treatments and personalized therapies. As we continue to explore these connections, we hope to contribute significantly to the ever-evolving field of cancer research, improving patient outcomes and advancing precision medicine in NSCLC.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza