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[Metabolite identification and metabolic pathway analysis of Platycodonis Radix extracts from Tongcheng city in rats].
Wang, Jing-Jing; Chang, Xiang-Wei; Wang, Xin-Rui; Zhi, Nan-Nan; Wang, Ju-Tao; Zha, Liang-Ping; Zhang, Xiao-Bo; Jiang, Chao; Gui, Shuang-Ying.
Afiliación
  • Wang JJ; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
  • Chang XW; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Hefei 230012, China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine Hefei 230012, China Anhu
  • Wang XR; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
  • Zhi NN; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
  • Wang JT; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
  • Zha LP; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Hefei 230012, China.
  • Zhang XB; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
  • Jiang C; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
  • Gui SY; School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Hefei 230012, China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine Hefei 230012, China Anhu
Zhongguo Zhong Yao Za Zhi ; 49(14): 3912-3923, 2024 Jul.
Article en Zh | MEDLINE | ID: mdl-39099365
ABSTRACT
In this study, we delved into the prototypical components and metabolites of Platycodonis Radix extracts(PRE) from Tongcheng city in plasma, urine and feces of rats, and revealed its metabolic pathways and metabolic rules in vivo. The prototypical components and metabolites of PRE in rats were characterized and identified by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) and mass defect filter(MDF). The biological samples were analyzed by ACQUITY UPLC BEH C_(18)(2.1 mm×100 mm, 1.7 µm), with 0.1% formic acid water(A)-0.1% formic acid acetonitrile(B) as mobile phase, and the biological samples were analyzed in negative ion mode by electrospray ionization mass spectrometry(ESI-MS). Twelve prototypical saponins and twenty-seven metabolites were detected in plasma, urine and feces of rats treated with PRE by oral administration. Eleven prototypical components and nine metabolites were detected in plasma, eleven prototypical components and eight metabo-lites were detected in urine, and ten prototypical components and twenty metabolites were detected in feces. Further studies showed that the metabolic pathways of PRE in rats mainly include oxidation, reduction, acetylation, stepwise hydrolytic deglycosylation, glucuronidation and so on. This study provides a scientific basis for clarifying the pharmacological basis and mechanism of PRE from Tongcheng city.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Ratas Sprague-Dawley / Platycodon / Redes y Vías Metabólicas Límite: Animals País/Región como asunto: Asia Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Ratas Sprague-Dawley / Platycodon / Redes y Vías Metabólicas Límite: Animals País/Región como asunto: Asia Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China