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Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia.
Bardini, Michela; Fazio, Grazia; Abascal, Lilia Corral; Meyer, Claus; Maglia, Oscar; Sala, Simona; Palamini, Sonia; Rebellato, Stefano; Marschalek, Rolf; Rizzari, Carmelo; Biondi, Andrea; Cazzaniga, Giovanni.
Afiliación
  • Bardini M; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Fazio G; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Abascal LC; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
  • Meyer C; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Maglia O; DCAL/Institute of Pharmaceutical Biology, Goethe-University, Frankfurt/Main, Germany.
  • Sala S; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Palamini S; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Rebellato S; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Marschalek R; Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Rizzari C; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
  • Biondi A; Pediatrics, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
  • Cazzaniga G; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Br J Haematol ; 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-39099338
ABSTRACT
Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B-cell precursor Acute Lymphoblastic Leukaemia (BCP-ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP-ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient-specific CUX1NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP-ALL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Br J Haematol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Br J Haematol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido