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Association of per- and polyfluoroalkyl substances with the antioxidant bilirubin across pregnancy.
Taibl, Kaitlin R; Dunlop, Anne L; Smith, M Ryan; Walker, Douglas I; Ryan, P Barry; Panuwet, Parinya; Corwin, Elizabeth J; Kannan, Kurunthachalam; Jones, Dean P; Marsit, Carmen J; Tan, Youran; Liang, Donghai; Eick, Stephanie M; Barr, Dana Boyd.
Afiliación
  • Taibl KR; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Dunlop AL; Department of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA, USA.
  • Smith MR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA; Atlanta VA Healthcare System, Decatur, GA, USA.
  • Walker DI; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Ryan PB; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Panuwet P; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Corwin EJ; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
  • Kannan K; Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Environmental Health Sciences, State University of New York at Albany, NY, USA.
  • Jones DP; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA.
  • Marsit CJ; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Tan Y; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Liang D; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Eick SM; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Barr DB; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: dbbarr@emory.edu.
Free Radic Biol Med ; 223: 184-192, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39097204
ABSTRACT

BACKGROUND:

In mechanistic and preliminary human studies, prenatal exposure to per- and polyfluoroalkyl substances (PFAS) is associated with oxidative stress, a potential contributor to maternal liver disease. Bilirubin is an endogenous antioxidant abundant in the liver that may serve as a physiological modulator of oxidative stress in pregnant people. Hence, our objective was to estimate the association between repeated measures of PFAS and bilirubin during pregnancy.

METHODS:

The study population included 332 participants in the Atlanta African American Maternal-Child Cohort between 2014 and 2020. Serum samples were collected up to two times (early pregnancy 6-18 gestational weeks; late pregnancy 21-36 gestational weeks) for the measurement of perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and total bilirubin. We analyzed single PFAS with linear mixed effect regression and a mixture of the four PFAS with quantile g-computation. Models were repeated with a multiplicative interaction term to explore effect modification by study visit.

RESULTS:

Overall, PFHxS was positively associated with bilirubin (ß = 0.08, 95 % CI = 0.01, 0.15). We also found during late pregnancy, there was a positive association of PFHxS and the PFAS mixture with bilirubin (ß = 0.12, 95 % CI = 0.02, 0.22; ψ = 0.19, 95 % CI = 0.03, 0.34, respectively). Finally, study visit modified the PFOA-bilirubin association (interaction p-value = 0.09), which was greater during early pregnancy (ß = 0.08, 95 % CI = 0.01, 0.15).

CONCLUSION:

In a prospective cohort of pregnant African Americans, an increase in PFOA, PFHxS, and the PFAS mixture was associated with an increase in bilirubin. Our results suggest that, depending on pregnancy stage, prenatal PFAS exposure disrupts the maternal liver antioxidant capacity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Caprilatos / Ácidos Alcanesulfónicos / Fluorocarburos / Antioxidantes Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Caprilatos / Ácidos Alcanesulfónicos / Fluorocarburos / Antioxidantes Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos