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Light in evaluation of molecular diffusion in tissues: Discrimination of pathologies.
Oliveira, Luís R; Pinheiro, Maria R; Tuchina, Daria K; Timoshina, Polina A; Carvalho, Maria I; Oliveira, Luís M.
Afiliación
  • Oliveira LR; Department of Public and Environmental Health, Polytechnic of Porto - School of Health (ESS), Porto, Portugal.
  • Pinheiro MR; Institute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal.
  • Tuchina DK; Institute of Physics and Science Medical Center, Saratov State University, Saratov, Russian Federation; Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Tomsk, Russian Federation.
  • Timoshina PA; Institute of Physics and Science Medical Center, Saratov State University, Saratov, Russian Federation; Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Tomsk, Russian Federation; Lomonosov Moscow State University, Moscow, Russian Federation.
  • Carvalho MI; Institute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal; Department of Electrical and Computer Engineering, Porto University - Faculty of Engineering, Porto, Portugal.
  • Oliveira LM; Institute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal; Physics Department, Polytechnic of Porto - School of Engineering (ISEP), Porto, Portugal. Electronic address: lmo@isep.ipp.pt.
Adv Drug Deliv Rev ; 212: 115420, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39096937
ABSTRACT
The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing ex vivo tissues in agents or by topical application of those agents in vivo, their diffusion properties can be evaluated by kinetic collimated transmittance or diffuse reflectance spectroscopy. Using this method, recent studies were able to discriminate the diffusion properties of agents between healthy and diseased tissues, especially in the cases of cancer and diabetes mellitus. In the case of cancer, it was also possible to evaluate an increase of 5% in the mobile water content from the healthy to the cancerous colorectal and kidney tissues. Considering the application of some agents to living organisms or food products to protect them from deterioration during low temperature preservation (cryopreservation), and knowing that such agent inclusion may be reversed, some studies in these fields are also discussed. Considering the broadband application of the optical spectroscopy evaluation of the diffusion properties of agents in tissues and the physiological diagnostic data that such method can acquire, further studies concerning the optimization of fruit sweetness or evaluation of poison diffusion in tissues or antidote application for treatment optimization purposes are indicated as future perspectives.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Países Bajos