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Head and neck squamous cell carcinoma (HNSCC) in solid organ transplant recipients - Results from the scientific registry of transplant recipients (SRTR) database.
Mukherjee, Amrita; Cui, Jinhong; Patel, Pranali G; Bhagia, Preeti; McCammon, Susan D; Varambally, Sooryanarayana; Shrestha, Sadeep.
Afiliación
  • Mukherjee A; Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA; Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA. Electronic address: amrita.x.mukherjee@kp.org.
  • Cui J; Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
  • Patel PG; Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
  • Bhagia P; Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
  • McCammon SD; Otolaryngology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
  • Varambally S; Molecular & Cellular Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
  • Shrestha S; Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Am J Otolaryngol ; 45(6): 104444, 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39096566
ABSTRACT

BACKGROUND:

Solid organ transplant recipients have an elevated risk of cancer following organ transplantation than the age-adjusted general population. We assessed incidence of head and neck squamous cell carcinoma (HNSCC) in heart, lung, and liver recipients. BASIC PROCEDURES/

METHODS:

This retrospective cohort study included 124,966 patients from the United States Scientific Registry of Transplant Recipients (SRTR) database who received heart, lung, or liver transplantation between 1991 and 2010. Follow-up data were available until 2018. Patients with prevalent HNSCC at transplantation were excluded. Incident cases of HNSCC post organ transplantation were identified, and incidence rates (per 100,000 person-years) were reported by gender, race, organ type, year and age at organ transplantation. MAIN

FINDINGS:

The majority of patients received liver transplantation (58.64 %), followed by heart (28.64 %), and lung (12.72 %) transplantation. During follow-up, 4.14 % patients developed HNSCC. Overall incidence rate of HNSCC was 426.76 per 100,000 person-years. Male recipients had a higher HNSCC incidence rate than female recipients (571.8 and 177.0 per 100,000 person-years, respectively). Lung recipients had the highest overall HNSCC incidence rate (1273.6 per 100,000 person-years), followed by heart (644.2 per 100,000 person-years), and liver recipients (207.1 per 100,000 person-years). Overall, an increase in HNSCC incidence rate was observed with increase in age at organ transplantation. An increase in incidence rates of HNSCC over time was observed in lung recipients; however, incidence rates decreased over time in heart recipients.

CONCLUSION:

Solid organ transplant recipients have a high incidence of HNSCC following organ transplantation, and the incidence varies by type of organ received.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Otolaryngol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Otolaryngol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos