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Cardio- and Vasoprotective Effects of Quinacrine in an In Vivo Rat Model of Myocardial Ischemia/Reperfusion Injury.
Sonin, D L; Pochkaeva, E I; Papayan, G V; Minasian, S M; Mukhametdinova, D V; Zaytseva, E A; Mochalov, D A; Petrishchev, N N; Galagudza, M M.
Afiliación
  • Sonin DL; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia. sonin_dl@almazovcentre.ru.
  • Pochkaeva EI; I. P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia. sonin_dl@almazovcentre.ru.
  • Papayan GV; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • Minasian SM; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • Mukhametdinova DV; I. P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • Zaytseva EA; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • Mochalov DA; I. P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • Petrishchev NN; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • Galagudza MM; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Bull Exp Biol Med ; 177(2): 190-196, 2024 Jun.
Article en En | MEDLINE | ID: mdl-39096448
ABSTRACT
This study aimed to investigate the cardioprotective effect of quinacrine in an in vivo model of myocardial ischemia/reperfusion injury. A 30-min regional myocardial ischemia followed by a 2-h reperfusion was modeled in anesthetized Wistar rats. Starting at the last minute of ischemia and during the first 9 min of reperfusion the rats in the control (n=8) and experimental (n=9) groups were injected with 0.9% NaCl and quinacrine solution (5 mg/kg), respectively. The area at risk and infarct size were evaluated by "double staining" with Evans blue and triphenyltetrazolium chloride. To assess vascular permeability in the area at risk zone, indocyanine green (ICG) and thioflavin S (ThS) were injected intravenously at the 90th and 120th minutes of reperfusion, respectively, to assess the no-reflow zone. The images of ICG and ThS fluorescence in transverse sections of rat hearts were obtained using a FLUM multispectral fluorescence organoscope. HR tended to decrease by 13% after intravenous administration of quinacrine and then recovered within 50 min. Quinacrine reduced the size of the necrotic zone (p=0.01), vascular permeability in the necrosis region, and the no-reflow area (p=0.027); at the same time, the area at risk did not significantly differ between the groups. Intravenous administration of quinacrine at the beginning of reperfusion of the rat myocardium reduces no-reflow phenomenon and infarct size.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinacrina / Cardiotónicos / Daño por Reperfusión Miocárdica / Ratas Wistar Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinacrina / Cardiotónicos / Daño por Reperfusión Miocárdica / Ratas Wistar Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos