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A High Dynamic Range Ion Detector for Multireflection Time-of-Flight Analyzers.
Stewart, Hamish; Petzoldt, Johannes; Shanley, Toby; Grinfeld, Dmitry; Denisov, Eduard; Hagedorn, Bernd; Dwivedi, Ankit; Mourad, Daniel; Ostermann, Robert; Ochmann, Maximilian; Cochems, Philipp; Wagner, Alexander; Balschun, Wilko; Makarov, Alexander; Shofman, Semyon; Moti, Ben-David; Weingarten, Amit; Kadyshevitch, Sasha; Hock, Christian.
Afiliación
  • Stewart H; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Petzoldt J; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Shanley T; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Grinfeld D; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Denisov E; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Hagedorn B; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Dwivedi A; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Mourad D; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Ostermann R; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Ochmann M; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Cochems P; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Wagner A; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Balschun W; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Makarov A; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
  • Shofman S; El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.
  • Moti BD; El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.
  • Weingarten A; El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.
  • Kadyshevitch S; El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.
  • Hock C; Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
J Am Soc Mass Spectrom ; 2024 Aug 03.
Article en En | MEDLINE | ID: mdl-39096288
ABSTRACT
Reflectron-based time-of-flight analyzers rely on subnanosecond detector time response to achieve acceptable resolving power for low-mid-mass, multiple-ion peaks. With the adoption of multireflection analyzers, order of magnitude longer folded ion paths relax restrictions on detector response time, allowing implementation of new technologies that greatly improve dynamic range, detector lifetime, and ion detection efficiency. A detection system is presented, integrated into a multireflection analyzer, that combines 10 keV postacceleration and focal plane correction with a unique BxE focusing, optically coupled detector, preamplification, and dual-channel digitization. Calibration and peak-handling methods are also described. The instrument demonstrated >1 × 104 dynamic range in a single shot, > 100k resolving power, and a relative immunity to detector aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Soc Mass Spectrom Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Soc Mass Spectrom Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos