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A dose-dependent bimodal switch by homologous Aux/IAA transcriptional repressors.
Cho, Hyung-Taeg; Lee, Minsu; Choi, Hee-Seung; Maeng, Kwang-Ho; Lee, Kyeonghoon; Lee, Ha-Yeon; Ganguly, Anindya; Park, Hoonyoung; Ho, Chang-Hoi.
Afiliación
  • Cho HT; Department of Biological Sciences, Seoul National University, Seoul, Korea. Electronic address: htcho@snu.ac.kr.
  • Lee M; Department of Biological Sciences, Seoul National University, Seoul, Korea.
  • Choi HS; Department of Biological Sciences, Seoul National University, Seoul, Korea.
  • Maeng KH; Department of Biological Sciences, Seoul National University, Seoul, Korea.
  • Lee K; Department of Biological Sciences, Seoul National University, Seoul, Korea.
  • Lee HY; Department of Biological Sciences, Seoul National University, Seoul, Korea.
  • Ganguly A; Department of Biological Sciences, Seoul National University, Seoul, Korea.
  • Park H; School of Earth and Environmental Sciences, Seoul National University, Seoul, Korea.
  • Ho CH; School of Earth and Environmental Sciences, Seoul National University, Seoul, Korea; Department of Climate and Energy Systems Engineering, Ewha Womans University, Seoul, Korea.
Mol Plant ; 17(9): 1407-1422, 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39095993
ABSTRACT
Combinatorial interactions between different regulators diversify and enrich the chance of transcriptional regulation in eukaryotic cells. However, a dose-dependent functional switch of homologous transcriptional repressors has rarely been reported. Here, we show that SHY2, an auxin/indole-3-acetic acid (Aux/IAA) repressor, exhibits a dose-dependent bimodal role in auxin-sensitive root-hair growth and gene transcription in Arabidopsis, whereas other Aux/IAA homologs consistently repress the auxin responses. The co-repressor (TOPLESS [TPL])-binding affinity of a bimodal Aux/IAA was lower than that of a consistently repressing Aux/IAA. The switch of a single amino acid residue in the TPL-binding motif between the bimodal form and the consistently repressing form switched their TPL-binding affinity and transcriptional and biological roles in auxin responses. Based on these data, we propose a model whereby competition between homologous repressors with different co-repressor-binding affinities could generate a bimodal output at the transcriptional and developmental levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Arabidopsis / Regulación de la Expresión Génica de las Plantas / Proteínas de Arabidopsis / Ácidos Indolacéticos Idioma: En Revista: Mol Plant Asunto de la revista: BIOLOGIA MOLECULAR / BOTANICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Arabidopsis / Regulación de la Expresión Génica de las Plantas / Proteínas de Arabidopsis / Ácidos Indolacéticos Idioma: En Revista: Mol Plant Asunto de la revista: BIOLOGIA MOLECULAR / BOTANICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido