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Psilocybin-assisted therapy and HIV-related shame.
Mehtani, Nicky J; Johnson, Mallory O; Hendricks, Peter S; Mitchell, Jennifer; Anderson, Brian T.
Afiliación
  • Mehtani NJ; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, Sandler Neurosciences Bldg., Rm 510, 675 Nelson Rising Lane, San Francisco, CA, 94143, USA. nicky.mehtani@ucsf.edu.
  • Johnson MO; Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA, USA. nicky.mehtani@ucsf.edu.
  • Hendricks PS; Department of Medicine, Division of Prevention Science, University of California, San Francisco, San Francisco, CA, USA.
  • Mitchell J; Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Anderson BT; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, Sandler Neurosciences Bldg., Rm 510, 675 Nelson Rising Lane, San Francisco, CA, 94143, USA.
Sci Rep ; 14(1): 17919, 2024 08 02.
Article en En | MEDLINE | ID: mdl-39095420
ABSTRACT
As a proposed mediator between stigma-related stressors and negative mental health outcomes, HIV-related shame has been predictive of increased rates of substance use and difficulties adhering to antiretroviral treatment among people with HIV. These downstream manifestations have ultimately impeded progress toward national goals to End the HIV Epidemic, in part due to limited success of conventional psychotherapies in addressing HIV-related shame. In a pilot clinical trial (N = 12), receipt of psilocybin-assisted group therapy was associated with a large pre-post decrease in HIV-related shame as measured by the HIV and Abuse Related Shame Inventory, with a median (IQR) change of - 5.5 (- 6.5, - 3.5) points from baseline to 3-months follow-up (Z = - 2.6, p = 0.009, r = - 0.75). A paradoxical exacerbation of sexual abuse-related shame experienced by two participants following receipt of psilocybin raises critical questions regarding the use of psilocybin therapy among patients with trauma. These preliminary findings carry potential significance for the future of HIV care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psilocibina / Vergüenza / Infecciones por VIH Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psilocibina / Vergüenza / Infecciones por VIH Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido