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Radiotherapy for central neurocytoma: A multicentric retrospective study in France.
Virbel, Guillaume; Mallereau, Charles-Henry; Lhermitte, Benoît; Feuvret, Loïc; Biau, Julian; Clément, Laurie; Khoury, Cédric; Bernier, Valérie; Milhade, Nicolas; Tanguy, Ronan; Colin, Philippe; Cébula, Hélène; Proust, François; Bauchet, Luc; Noël, Georges.
Afiliación
  • Virbel G; Department of Radiation Oncology, Unicancer, institut de cancérologie Strasbourg Europe (ICANS), 17, rue Albert-Calmette, BP 23025, 67033 Strasbourg, France.
  • Mallereau CH; Department of Neurosurgery, CHU de Hautepierre, 1, rue Molière, 67200 Strasbourg, France.
  • Lhermitte B; Department of Anatomopathology, CHU de Hautepierre, 1, rue Molière, 67200 Strasbourg, France.
  • Feuvret L; Department of Radiation Oncology, CHU de Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
  • Biau J; Department of Radiation Oncology, centre de lute contre le cancer Jean-Perrin, Unicancer, 58, rue Montalembert, 63011 Clermont-Ferrand, France.
  • Clément L; Department of Radiation Oncology, CHU Bretonneau, 2, boulevard Tonnellé, 37000 Tours, France.
  • Khoury C; Department of Radiation Oncology, centre de radiothérapie Saint-Louis Croix-Rouge française, 150, rue Nicolas-Appert, 83100 Toulon, France.
  • Bernier V; Department of Radiation Oncology, institut du cancer de Lorraine - Alexis-Vautrin, Unicancer, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
  • Milhade N; Department of Radiation Oncology, institut Bergonié, Unicancer, 229, cour de l'Argonne, 33076 Bordeaux, France.
  • Tanguy R; Department of Radiation Oncology, centre Léon-Bérard, Unicancer, 28, promenade Léa-et-Napoléon-Bullukian, 69008 Lyon, France.
  • Colin P; Department of Radiation Oncology, polyclinique Courlancy, 38, rue de Courlancy, 51100 Reims, France.
  • Cébula H; Department of Neurosurgery, CHU de Hautepierre, 1, rue Molière, 67200 Strasbourg, France.
  • Proust F; Department of Neurosurgery, CHU de Hautepierre, 1, rue Molière, 67200 Strasbourg, France.
  • Bauchet L; Department of Neurosurgery, hôpital Gui-de-Chauliac, CHU de Montpellier, 80, avenue Augustin-Fliche, 34090 Montpellier, France; IGF, Inserm U1191, Montpellier, France.
  • Noël G; Department of Radiation Oncology, Unicancer, institut de cancérologie Strasbourg Europe (ICANS), 17, rue Albert-Calmette, BP 23025, 67033 Strasbourg, France. Electronic address: g.noel@icans.eu.
Cancer Radiother ; 28(4): 365-372, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39095224
ABSTRACT

PURPOSE:

Neurocytomas represent 0.25 to 0.5% of primary brain tumours and are mainly found in young adults. These tumours have neuronal differentiation. The cornerstone treatment is neurosurgery. The efficacy of other therapies, including radiotherapy, is still unclear. The objective of this study was to evaluate the management of central neurocytomas and the role of radiotherapy. MATERIALS AND

METHODS:

All adult patients (age 18 years or older) newly diagnosed with a histologically confirmed neurocytoma between 2006 and 2015 in France were included.

RESULTS:

One hundred and sixteen patients were diagnosed with a central neurocytoma during the study period. All patients underwent surgical resection, and six received adjuvant radiotherapy. Eleven patients received radiotherapy due to progression. After a median follow-up of 68.7 months, local failure occurred in 29 patients. The 5-year local control rate was 73.4%. According to univariate analysis, marker of proliferation Ki67 index greater than 2% (hazard ratio [HR] 1.48; confidence interval [CI] 1.40-1.57; P=0.027) and subtotal resection (HR 8.48; CI 8.01-8.99; P<0.001) were associated with an increase in local failure. Gross total resection was associated with a higher risk of sequelae epilepsy (HR 3.62; CI 3.42-3.83; P<0.01) and memory disorders (HR 1.35; CI 1.07-1.20; P<0.01). Ten patients (8.6%) died during the follow-up. The 10-year overall survival rate was 89.0%. No prognostic factors for overall survival were found.

CONCLUSION:

The analysis showed that patients who underwent subtotal surgical resection, particularly when the tumour had a Ki67 index greater than 2%, had an increased risk of local recurrence. These patients could benefit from adjuvant radiotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neurocitoma Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Cancer Radiother Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neurocitoma Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Cancer Radiother Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia