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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus.
Wang, Kun; Shi, Xu; Lin, Hongjin; Xu, Tong; Xu, Shiwen.
Afiliación
  • Wang K; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
  • Shi X; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
  • Lin H; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
  • Xu T; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address: tongxu@neau.edu.cn.
  • Xu S; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, China. Electronic address: shiwenxu@neau.edu.cn.
J Environ Sci (China) ; 148: 13-26, 2025 Feb.
Article en En | MEDLINE | ID: mdl-39095152
ABSTRACT
Bisphenol A (BPA) is an industrial pollutant that can cause immune impairment. Selenium acts as an antioxidant, as selenium deficiency often accompanies oxidative stress, resulting in organ damage. This study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell (MDCC-MSB-1) via oxidative stress-induced endoplasmic reticulum (ER) stress. We established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 days. The results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities (T-AOC, CAT, and GSH-Px), accumulation of peroxides (H2O2 and MDA), significant upregulation of ER stress-related markers (GRP78, IER 1, PERK, EIF-2α, ATF4, and CHOP), a significant increase in iron ion levels, significant upregulation of pyroptosis-related gene (NLRP3, ASC, Caspase1, GSDMD, IL-18 and IL-1ß), significantly increase ferroptosis-related genes (TFRC, COX2) and downregulate GPX4, HO-1, FTH, NADPH. In vitro experiments conducted in MDCC-MSB-1 cells confirmed the results, demonstrating that the addition of antioxidant (NAC), ER stress inhibitor (TUDCA) and pyroptosis inhibitor (Vx765) alleviated oxidative stress, endoplasmic reticulum stress, pyroptosis, and ferroptosis. Overall, this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Selenio / Compuestos de Bencidrilo / Pollos / Especies Reactivas de Oxígeno / Estrés del Retículo Endoplásmico / Piroptosis / Ferroptosis Límite: Animals Idioma: En Revista: J Environ Sci (China) Asunto de la revista: SAUDE AMBIENTAL Año: 2025 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Selenio / Compuestos de Bencidrilo / Pollos / Especies Reactivas de Oxígeno / Estrés del Retículo Endoplásmico / Piroptosis / Ferroptosis Límite: Animals Idioma: En Revista: J Environ Sci (China) Asunto de la revista: SAUDE AMBIENTAL Año: 2025 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos