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Efficacy and safety of COVID-19 vaccination in solid organ transplant recipients: A systematic review and network meta-analysis.
Rayner, Daniel G; Nunes, Jairo T; Gou, David; Chu, Alexandro W L; Dai, Si-Cheng; Sheikh, Aleesha; Meng, Dorisa; Orchanian-Cheff, Ani; Oss, Shelly; Rotstein, Coleman; Aleksova, Natasha; Foroutan, Farid.
Afiliación
  • Rayner DG; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Nunes JT; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada.
  • Gou D; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Chu AWL; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Dai SC; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Sheikh A; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Meng D; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Orchanian-Cheff A; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada.
  • Oss S; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada.
  • Rotstein C; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada.
  • Aleksova N; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada.
  • Foroutan F; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada. Electronic address: farid.foroutan@uhn.ca.
Am J Transplant ; 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39094949
ABSTRACT
The impact of COVID-19 vaccination on clinical outcomes in solid organ transplant (SOT) recipients remains unclear. This systematic review and network meta-analysis sought to assess the efficacy and safety of COVID-19 vaccination in SOT recipients. We searched 6 databases from inception to March 1, 2024 for randomized controlled trials (RCTs) and observational studies evaluating different COVID-19 vaccination strategies in SOT recipients. Based on patient-important outcomes, we performed frequentist random-effects pairwise meta-analyses and network meta-analyses, separating RCTs and nonrandomized evidence, and used the Grading of Recommendation, Assessment, Development, and Evaluation approach to assess our certainty in the evidence. We included 6 RCTs (N = 814) and 43 observational studies (N = 125 199). Overall, there is a paucity of randomized evidence evaluating COVID-19 vaccines in SOT recipients. The nonrandomized evidence evaluating COVID-19 vaccination strategies patient-important outcomes, including COVID-19 infection, mortality, hospitalization, ICU admission, and rejection, demonstrated low to very low certainty due to the included studies' risk of bias. Throughout the COVID-19 pandemic, clinicians and SOT recipients worked with minimal, very low-quality evidence in relation to COVID-19 vaccines in this population. In the instance of future public health emergencies, clinicians and researchers should collaborate closely with patient partners to ensure there is sufficient evidence in the transplant population on patient-important outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos