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Gabapentin alleviates peripheral nerve sensitization induced by inflammatory arthritis via ionotropic glutamate receptor NR2B subunit.
Meng, Yu; Tan, Min; Yan Jiang, Xiang; Wang, Tao; Li Shen, Hai.
Afiliación
  • Meng Y; Department of Pain, The Lanzhou University Second Hospital, Lanzhou, PR China.
  • Tan M; Department of Rheumatology and Immunology, The Lanzhou University Second Hospital, Lanzhou, PR China.
  • Yan Jiang X; Department of General Surgery, The Lanzhou University Second Hospital, Lanzhou, PR China.
  • Wang T; Department of General Surgery, The Lanzhou University Second Hospital, Lanzhou, PR China.
  • Li Shen H; Department of Rheumatology and Immunology, The Lanzhou University Second Hospital, Lanzhou, PR China. Electronic address: shenhl@lzu.edu.cn.
Neuroscience ; 556: 1-13, 2024 Sep 25.
Article en En | MEDLINE | ID: mdl-39094822
ABSTRACT
Inflammatory arthritis leads to peripheral nerve sensitization, but the therapeutic effect is often unsatisfactory. Our preliminary studies have found that in mice with inflammatory arthritis, the use of ionotropic glutamate receptor antagonists can produce a good analgesic effect without altering foot swelling, suggesting that pain relief may be related to the improvement of neuropathic pain. However, the underlying mechanisms remain unclear. To further investigate the effects of neuropathic pain medications on inflammatory arthritis and the impact of the ionotropic glutamate receptor NR2B subunit (NR2B) on inflammatory arthritis, this study employed gabapentin (GBP) treatment on the inflammatory arthritis mouse model (the adjuvant induced arthritis, AIA), and we found a significant reduction in pain. Further studies revealed that in AIA, the expression levels of NR2B, TRPV1, pain-related molecules (substance P, PGE2), inflammatory cytokines (IL-1, IL-6, TNF-α, and GM-CSF) and Ca2+ were elevated in the foot and dorsal root ganglia (DRG). GBP treatment was able to influence the downregulation of the expression levels of NR2B, TRPV1, pain-related molecules, inflammatory cytokines and Ca2+. Mechanistic studies have shown that GBP treatment affects the downregulation of NR2B, and the downregulation of NR2B expression leads to the downregulation of TRPV1, pain-related molecules and inflammatory cytokines, thereby alleviating pain. These results suggest that in peripheral sensitization caused by AIA, GBP can play a role in improving pain, and NR2B may be a key target of peripheral nerve sensitization induced by inflammatory arthritis. GBP provides a theoretical basis for the clinical treatment of inflammatory arthritis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de N-Metil-D-Aspartato / Gabapentina / Analgésicos Límite: Animals Idioma: En Revista: Neuroscience Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de N-Metil-D-Aspartato / Gabapentina / Analgésicos Límite: Animals Idioma: En Revista: Neuroscience Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos